KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4.
KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4.
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KIF23 是神经胶质瘤中的独立预后生物标志物，受 TCF-4 转录调控
DOI：
10.18632/oncotarget.8261
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发表时间：
2016-04-26
期刊：
影响因子：
--
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Sun L;Zhang C;Yang Z;Wu Y;Wang H;Bao Z;Jiang T
驱动蛋白家族成员 23 (KIF23) 是一种核蛋白，也是细胞胞质分裂的关键调节因子，已被发现作为胶质瘤中的癌基因过度表达。然而，KIF23表达的胶质瘤的预后和临床病理特征尚不清楚。在这里，我们利用中国胶质瘤基因组图谱（CGGA）数据库（http://www.cgga.org.cn）的全基因组mRNA表达微阵列数据分析了KIF23的表达模式，发现KIF23过表达与高级别胶质瘤以及生存分析中的较高死亡率显着相关（对数秩检验，p<0.01）。其他三个验证数据集的结果显示了类似的发现。此外，KIF23 还可以作为神经胶质瘤患者的独立预后生物标志物。最后，功能测定表明，KIF23 的减少可抑制体内和体外神经胶质瘤细胞的增殖。此外，我们发现 KIF23 在转录水平上受到 TCF-4 的调节。因此，这一证据表明 KIF23 过度表达与神经胶质瘤恶性肿瘤相关，并导致神经胶质瘤的生存时间较短，这表明 KIF23 是一种新的新型预后生物标志物，对神经胶质瘤具有潜在的治疗意义。
Kinesin family member 23 (KIF23), a nuclear protein and a key regulator of cellular cytokinesis, has been found to be overexpressed as an oncogene in glioma. However, the prognostic and clinicopathological features of glioma with KIF23 expression was not clear yet. Here, we analyzed KIF23 expression pattern by using whole genome mRNA expression microarray data from Chinese Glioma Genome Atlas (CGGA) database (http://www.cgga.org.cn), and found that KIF23 overexpression was significantly associated with high grade glioma as well as the higher mortality in survival analysis (log-rank test, p<0.01). The results of the three other validation datasets showed similar findings. Furthermore, KIF23 also served as an independent prognostic biomarker in glioma patients. Finally, functional assay showed that reduction of KIF23 suppressed glioma cell proliferation both in vivo and vitro. Additionally, we found that KIF23 was regulated by TCF-4 at transcriptionally level. Therefore, this evidence indicates KIF23 over-expression is associated with glioma malignancy and conferred a worse survival time in glioma, which suggests KIF23 is a new novel prognostic biomarker with potential therapeutic implications in glioma.
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