Replicative and chronological aging in Saccharomyces cerevisiae.
Replicative and chronological aging in Saccharomyces cerevisiae.
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DOI：
10.1016/j.cmet.2012.06.002
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发表时间：
2012-07-03
期刊：
影响因子：
29
通讯作者：
Kennedy B
中科院分区：
文献类型：
--
作者：
Longo VD;Shadel GS;Kaeberlein M;Kennedy B
酿酒酵母已经直接或间接地鉴定了比任何其他模式生物更多的影响衰老的哺乳动物基因。酵母中的老化主要通过测量复制或时间寿命来测定。在这里，我们回顾了这两个衰老模型系统中涉及的基因和机制，以及优化这些检测方法需要解决的关键问题。由于其基因组和蛋白质组的良好特征，非常适合遗传操作和高通量筛选程序，S。酿酒酵母将继续作为研究人类衰老和疾病相关途径的主要模式生物。
Saccharomyces cerevisiae has directly or indirectly contributed to the identification of arguably more mammalian genes that affect aging than any other model organism. Aging in yeast is assayed primarily by measuring replicative or chronological lifespan. Here, we review the genes and mechanisms implicated in these two aging model systems and key remaining issues that need to be addressed to optimize these assays. Because of its well-characterized genome and proteome that is remarkably amenable to genetic manipulation and high-throughput screening procedures, S. cerevisiae will continue to serve as a leading model organism to study pathways relevant to human aging and disease.
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影响因子：
7.8
作者：
Delaney JR;Sutphin GL;Dulken B;Sim S;Kim JR;Robison B;Schleit J;Murakami CJ;Carr D;An EH;Choi E;Chou A;Fletcher M;Jelic M;Liu B;Lockshon D;Moller RM;Pak DN;Peng Q;Peng ZJ;Pham KM;Sage M;Solanky A;Steffen KK;Tsuchiya M;Tsuchiyama S;Johnson S;Raabe C;Suh Y;Zhou Z;Liu X;Kennedy BK;Kaeberlein M
通讯作者：
Kaeberlein M
影响因子：
7.8
作者：
Alvers AL;Fishwick LK;Wood MS;Hu D;Chung HS;Dunn WA Jr;Aris JP
通讯作者：
Aris JP
影响因子：
64.8
作者：
Burnett, Camilla;Valentini, Sara;Cabreiro, Filipe;Goss, Martin;Somogyvari, Milan;Piper, Matthew D.;Hoddinott, Matthew;Sutphin, George L.;Leko, Vid;McElwee, Joshua J.;Vazquez-Manrique, Rafael P.;Orfila, Anne-Marie;Ackerman, Daniel;Au, Catherine;Vinti, Giovanna;Riesen, Michele;Howard, Ken;Neri, Christian;Bedalov, Antonio;Kaeberlein, Matt;Soti, Csaba;Partridge, Linda;Gems, David
通讯作者：
Gems, David
影响因子：
4.3
作者：
Burtner, Christopher R.;Murakami, Christopher J.;Kaeberlein, Matt
通讯作者：
Kaeberlein, Matt
影响因子：
7.5
作者：
Dechant, Reinhard;Peter, Matthias
通讯作者：
Peter, Matthias