Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation.
Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation.
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DOI：
10.3389/fncel.2013.00022
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发表时间：
2013
影响因子：
5.3
通讯作者：
Wong WT
中科院分区：
文献类型：
--
作者：
Wong WT
神经退行性疾病如阿尔茨海默病、帕金森病和年龄相关性黄斑变性（AMD）共有两个共同特征：（1）疾病患病率随着年龄的增长而显著增加，和（2）神经炎性变化，其中小胶质细胞（CNS的主要驻留免疫细胞）具有显著特征。这些特征导致了这样的假设，即年龄相关性神经退行性疾病的致病机制涉及小胶质细胞的衰老变化。如果正确的话，靶向小胶质细胞衰老的特征可能构成一种可行的治疗策略。这篇综述探讨了这一假设及其影响，考虑到目前的知识，小胶质细胞如何在衰老过程中发生变化，以及这些衰老表型的出现如何与小胶质细胞功能的显着改变。证据和理论的细胞机制，涉及在驱动小胶质细胞衰老的审查，是“返老还童”的措施和策略，旨在扭转或改善老化的小胶质细胞表型。了解和控制小胶质细胞衰老可能是阐明疾病机制和制定新疗法的机会。
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and age-related macular degeneration (AMD), share two characteristics in common: (1) a disease prevalence that increases markedly with advancing age, and (2) neuroinflammatory changes in which microglia, the primary resident immune cell of the CNS, feature prominently. These characteristics have led to the hypothesis that pathogenic mechanisms underlying age-related neurodegenerative disease involve aging changes in microglia. If correct, targeting features of microglial senescence may constitute a feasible therapeutic strategy. This review explores this hypothesis and its implications by considering the current knowledge on how microglia undergo change during aging and how the emergence of these aging phenotypes relate to significant alterations in microglial function. Evidence and theories on cellular mechanisms implicated in driving senescence in microglia are reviewed, as are “rejuvenative” measures and strategies that aim to reverse or ameliorate the aging microglial phenotype. Understanding and controlling microglial aging may represent an opportunity for elucidating disease mechanisms and for formulating novel therapies.
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DOI：
10.1073/pnas.1205858109
发表时间：
2012-09-11
影响因子：
11.1
作者：
Capotondo, Alessia;Milazzo, Rita;Biffi, Alessandra
通讯作者：
Biffi, Alessandra
影响因子：
4.2
作者：
Bachstetter, Adam D.;Morganti, Josh M.;Jernberg, Jennifer;Schlunk, Andrea;Mitchell, Staten H.;Brewster, Kaelin W.;Hudson, Charles E.;Cole, Michael J.;Harrison, Jeffrey K.;Bickford, Paula C.;Gemma, Carmelina
通讯作者：
Gemma, Carmelina
DOI：
10.1523/jneurosci.2173-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barrientos RM;Hein AM;Frank MG;Watkins LR;Maier SF
通讯作者：
Maier SF
影响因子：
2.5
作者：
Bartzokis, G;Beckson, M;Marder, SR
通讯作者：
Marder, SR
影响因子：
4.2
作者：
Campuzano, O.;Castillo-Ruiz, M. M.;Gonzalez, B.
通讯作者：
Gonzalez, B.