Modafinil for the treatment of cocaine dependence.
Modafinil for the treatment of cocaine dependence.
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DOI：
10.1016/j.drugalcdep.2009.04.015
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发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Elkashef, Ahmed M.
中科院分区：
文献类型：
--
作者：
Anderson, Ann L.;Reid, Malcolm S.;Li, Shou-Hua;Holmes, Tyson;Shemanski, Lynn;Slee, April;Smith, Edwina V.;Kahn, Roberta;Chiang, Nora;Vocci, Frank;Ciraulo, Domenic;Dackis, Charles;Roache, John D.;Salloum, Ihsan M.;Somoza, Eugene;Urschel, Harold C., III;Elkashef, Ahmed M.
与安慰剂相比，莫达非尼在促进可卡因依赖患者戒断方面的疗效进行了测试。这是一项双盲安慰剂对照研究，治疗12周，随访4周。六个门诊药物滥用治疗诊所参加了这项研究。有210名被诊断为可卡因依赖的寻求治疗者被随机分配; 72名参与者被随机分配到安慰剂组，69名参与者被随机分配到莫达非尼200 mg组，69名参与者被随机分配到莫达非尼400 mg组，每天服用一次。参与者每周来诊所三次进行评估和尿液药物筛查，每周进行一小时的个人心理治疗。主要结果指标是每周可卡因非使用天数的百分比。GEE回归分析显示，对于总样本，在12周治疗期间，莫达非尼组和安慰剂组之间可卡因未使用天数的平均每周百分比变化无显著差异（p > 0.79）。然而，两个次要结果显示莫达非尼200 mg的显著效果：可卡因连续不使用天数的最大值（p = 0.02）和渴望的减少（p = 0.04）。此外，事后分析显示莫达非尼的显著效果，增加了那些没有酒精依赖史的可卡因患者亚组中每周不使用天数的百分比（p < 0.02）。这些数据表明，莫达非尼，与个人行为疗法相结合，是有效的增加可卡因非使用天的参与者没有共病酒精依赖，并在减少可卡因的渴望。
Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo. This was a double-blind placebo-controlled study, with 12 weeks of treatment and a 4-week follow-up. Six outpatient substance abuse treatment clinics participated in the study. There were 210 treatment-seekers randomized, having a diagnosis of cocaine dependence; 72 participants were randomized to placebo, 69 to modafinil 200 mg, and 69 to modafinil 400 mg, taken once daily on awakening. Participants came to the clinic three times per week for assessments and urine drug screens, and had one hour of individual psychotherapy weekly. The primary outcome measure was the weekly percentage of cocaine non-use days. The GEE regression analysis showed that for the total sample, there was no significant difference between either modafinil group and placebo in the change in average weekly percent of cocaine non-use days over the 12-week treatment period (p > 0.79). However, two secondary outcomes showed significant effects by modafinil 200 mg: the maximum number of consecutive non-use days for cocaine (p = 0.02), and a reduction in craving (p = 0.04). Also, a post hoc analysis showed a significant effect of modafinil that increased the weekly percentage of non-use days in the subgroup of those cocaine patients who did not have a history of alcohol dependence (p < 0.02). These data suggest that modafinil, in combination with individual behavioral therapy, was effective for increasing cocaine non-use days in participants without co-morbid alcohol dependence, and in reducing cocaine craving.
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影响因子：
10.6
作者：
Turner, DC;Clark, L;Sahakian, BJ
通讯作者：
Sahakian, BJ
影响因子：
5.3
作者：
Scammell, TE;Estabrooke, IV;Saper, CB
通讯作者：
Saper, CB
影响因子：
4.2
作者：
Kampman, KM;Pettinati, H;O'Brien, CP
通讯作者：
O'Brien, CP
DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
影响因子：
3.9
作者：
Hser, YI;Stark, ME;Rawson, R
通讯作者：
Rawson, R