FurinDB: A database of 20-residue furin cleavage site motifs, substrates and their associated drugs.
FurinDB: A database of 20-residue furin cleavage site motifs, substrates and their associated drugs.
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FurinDB：20 残基弗林蛋白酶切割位点基序、底物及其相关药物的数据库
DOI：
10.3390/ijms12021060
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发表时间：
2011-02-08
影响因子：
5.6
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Tian S;Huang Q;Fang Y;Wu J
FurinDB（免费在线http://www.nuolan.net/substrates.html）是一个关于furin底物的数据库。该数据库包括经过实验验证的furin裂解位点、底物、种类、实验方法、实验原始出版物和靶向furin底物的相关药物。目前发布的数据库包含来自哺乳动物、细菌和病毒三种物种的126个furin切割位点。该数据库的一个主要特点是，所有的糠蛋白裂解位点都被记录为一个20残基基序，包括一个核心区域（8个氨基酸，P6-P2 ‘）和两个侧翼溶剂可达区域（8个氨基酸，P7-P14和4个氨基酸，P3 ’ -P6 '），这代表了我们目前对糠蛋白裂解的分子生物学的理解。该数据库对于理解furin裂解所需的序列基序、三维结构、细胞功能和物理性质之间的分子进化和关系，以及阐明furin裂解相关的人类疾病的分子机制和进展具有重要意义，包括致病性感染、神经系统疾病、肿瘤发生、肿瘤侵袭、血管生成和转移。对于分子生物学领域的科学家来说，FurinDB数据库将是公共基础设施的坚实补充。
FurinDB (freely available online at http://www.nuolan.net/substrates.html) is a database of furin substrates. This database includes experimentally verified furin cleavage sites, substrates, species, experimental methods, original publications of experiments and associated drugs targeting furin substrates. The current database release contains 126 furin cleavage sites from three species: mammals, bacteria and viruses. A main feature of this database is that all furin cleavage sites are recorded as a 20-residue motif, including one core region (eight amino acids, P6–P2′) and two flanking solvent accessible regions (eight amino acids, P7–P14, and four amino acids, P3′–P6′), that represent our current understanding of the molecular biology of furin cleavage. This database is important for understanding the molecular evolution and relationships between sequence motifs, 3D structures, cellular functions and physical properties required by furin for cleavage, and for elucidating the molecular mechanisms and the progression of furin cleavage associated human diseases, including pathogenic infections, neurological disorders, tumorigenesis, tumor invasion, angiogenesis, and metastasis. FurinDB database will be a solid addition to the publicly available infrastructure for scientists in the field of molecular biology.
影响因子：
19
作者：
Molloy, SS;Anderson, ED;Thomas, G
通讯作者：
Thomas, G
影响因子：
2.9
作者：
Seidah, NG;Chrétien, M
通讯作者：
Chrétien, M
影响因子：
3.7
作者：
Hajdin K;D'Alessandro V;Niggli FK;Schäfer BW;Bernasconi M
通讯作者：
Bernasconi M