Shear wave elastography can stratify rectal cancer response to short-course radiation therapy.
Shear wave elastography can stratify rectal cancer response to short-course radiation therapy.
复制标题
DOI：
10.1038/s41598-023-43383-5
复制
发表时间：
2023-09-26
影响因子：
4.6
通讯作者：
Doyley, Marvin M.
中科院分区：
文献类型：
--
作者：
Mislati, Reem;Uccello, Taylor P.;Lin, Zixi;Iliza, Katia T.;Toussaint, Kimani C.;Gerber, Scott A.;Doyley, Marvin M.
直肠癌是一种致命的疾病，通常采用新辅助放化疗，然后进行全直肠系膜切除手术治疗。为了减少肿瘤从单独的新辅助治疗中消退的患者的直肠系膜切除手术的发生，在手术前使用常规成像，例如计算机断层扫描（CT）或磁共振成像（MRI）来评估肿瘤对新辅助治疗的反应。在这项工作中，我们假设剪切波弹性成像为肿瘤对短程放射治疗（SCRT）的反应提供了有价值的见解-这些信息可以帮助区分辐射反应性肿瘤和辐射非反应性肿瘤，并揭示可能影响辐射反应的肿瘤微环境变化。为了检验这一假设，我们在肿瘤细胞注射后第6、10、12、16、18、20、23和25天对小鼠直肠肿瘤（n = 32）进行弹性成像。该研究表明，辐射响应性和非辐射响应性肿瘤具有不同的机械特性。具体地，在SCRT后11天，辐射无响应肿瘤显示出比辐射响应肿瘤显著更高的剪切波速度SWS（p < 0.01）。此外，与SCRT后仅一天测量的剪切波衰减（SWA）相比，SCRT后16天辐射无反应肿瘤中的SWA（p < 0.01）存在显著差异。这些结果表明，剪切波弹性成像的潜力，以提供有价值的见解肿瘤反应SCRT和帮助探索潜在的生物学驱动肿瘤的辐射反应。
Rectal cancer is a deadly disease typically treated using neoadjuvant chemoradiotherapy followed by total mesorectal excision surgery. To reduce the occurrence of mesorectal excision surgery for patients whose tumors regress from the neoadjuvant therapy alone, conventional imaging, such as computed tomography (CT) or magnetic resonance imaging (MRI), is used to assess tumor response to neoadjuvant therapy before surgery. In this work, we hypothesize that shear wave elastography offers valuable insights into tumor response to short-course radiation therapy (SCRT)—information that could help distinguish radiation-responsive from radiation-non-responsive tumors and shed light on changes in the tumor microenvironment that may affect radiation response. To test this hypothesis, we performed elastographic imaging on murine rectal tumors (n = 32) on days 6, 10, 12, 16, 18, 20, 23, and 25 post-tumor cell injection. The study revealed that radiation-responsive and non-radiation-responsive tumors had different mechanical properties. Specifically, radiation-non-responsive tumors showed significantly higher shear wave speed SWS (p < 0.01) than radiation-responsive tumors 11 days after SCRT. Furthermore, there was a significant difference in shear wave attenuation (SWA) (p < 0.01) in radiation-non-responsive tumors 16 days after SCRT compared to SWA measured just one day after SCRT. These results demonstrate the potential of shear wave elastography to provide valuable insights into tumor response to SCRT and aid in exploring the underlying biology that drives tumors' responses to radiation.
登录
查看更多内容
DOI：
10.1109/tuffc.2016.2634329
发表时间：
2017-03-01
影响因子：
3.6
作者：
Bernard, Simon;Kazemirad, Siavash;Cloutier, Guy
通讯作者：
Cloutier, Guy
DOI：
10.1073/pnas.1213353109
发表时间：
2012-09-18
影响因子：
11.1
作者：
Stylianopoulos, Triantafyllos;Martin, John D.;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
DOI：
10.1146/annurev-bioeng-071813-105259
发表时间：
2014-07-11
影响因子：
9.7
作者：
Jain RK;Martin JD;Stylianopoulos T
通讯作者：
Stylianopoulos T
影响因子：
6.6
作者：
Basson MD;Zeng B;Downey C;Sirivelu MP;Tepe JJ
通讯作者：
Tepe JJ
影响因子：
2.9
作者：
Rombouts AJM;Al-Najami I;Abbott NL;Appelt A;Baatrup G;Bach S;Bhangu A;Garm Spindler KL;Gray R;Handley K;Kaur M;Kerkhof E;Kronborg CJ;Magill L;Marijnen CAM;Nagtegaal ID;Nyvang L;Peters FP;Pfeiffer P;Punt C;Quirke P;Sebag-Montefiore D;Teo M;West N;de Wilt JHW;for STAR-TREC Collaborative Group
通讯作者：
for STAR-TREC Collaborative Group