Exerkines and redox homeostasis.
Exerkines and redox homeostasis.
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DOI：
10.1016/j.redox.2023.102748
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发表时间：
2023-07
期刊：
影响因子：
11.4
通讯作者：
Stanford, Kristin I.
中科院分区：
文献类型：
--
作者：
Felix-Soriano, Elisa;Stanford, Kristin I.
运动生理学因其促进健康的广泛作用而受到越来越多的关注。近年来，这一研究领域也出现了增长，这也是因为发现了几个调节运动效果的循环因素。这些因子被称为激动素，是运动过程中主要代谢器官分泌的代谢产物、生长因子和细胞因子，以调节运动的全身和组织特异性效应。激动素的代谢效应已经被广泛研究，并需要一个有希望的目标来调节运动对健康和疾病的有益影响。然而，在改善应激反应的几个细胞过程中，激动素也有广泛的作用来调节氧化还原信号和动态平衡。由于氧化还原生物学是运动生理学的核心，本文综述了氧化还原生物学与激动素作用之间相互作用的现有证据。激动素在氧化还原生物学中的作用需要对氧化应激诱导的病理信号做出反应，以改善健康结果，并调节整合氧化还原信号的运动适应。
Exercise physiology has gained increasing interest due to its wide effects to promote health. Recent years have seen a growth in this research field also due to the finding of several circulating factors that mediate the effects of exercise. These factors, termed exerkines, are metabolites, growth factors, and cytokines secreted by main metabolic organs during exercise to regulate exercise systemic and tissue-specific effects. The metabolic effects of exerkines have been broadly explored and entail a promising target to modulate beneficial effects of exercise in health and disease. However, exerkines also have broad effects to modulate redox signaling and homeostasis in several cellular processes to improve stress response. Since redox biology is central to exercise physiology, this review summarizes current evidence for the cross-talk between redox biology and exerkines actions. The role of exerkines in redox biology entails a response to oxidative stress-induced pathological cues to improve health outcomes and to modulate exercise adaptations that integrate redox signaling.
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