Swimming in synthetic mucus
Swimming in synthetic mucus
复制标题
在合成粘液中游泳
DOI：
10.1109/urai.2017.7992656
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
M. J. Kim
中科院分区：
文献类型：
--
作者：
L. Rogowski;Hoyeon Kim;Xiao Zhang;Samuel Sheckman;Daehee Kim;M. J. Kim
微型机器人有潜力通过体内手术和靶向药物输送为医学科学提供重大突破。然而，在非牛顿粘液环境中应用微型机器人的研究受到限制。本文旨在展示微型游泳机器人在合成粘液中的游泳能力。微型游泳机器人是由铁磁珠连接在一起的线性链。微型游泳器可以使用旋转磁场平移通过感兴趣的流体介质。使用来自猪胃的干燥粘蛋白并与不同浓度的去离子水混合来开发合成粘液。然后使用流变仪分析这些配方以了解其流变特性。然后将微型游泳器插入这些合成粘液制剂中，并以不同的频率启动。利用计算机视觉技术提取微型游泳者的速度。有趣的是，微型游泳者能够在高达5%的粘蛋白浓度下游泳，然而，在如此高的浓度下，微型游泳者的表现往往不一致。通常情况下，microswimmer不传统的三珠组件比传统的三珠游泳者在过去的研究中进行了调查。这些结果表明，较小且不太复杂的游泳者可用于体内使用。
Microrobots have the potential to provide major break throughs in medical science through in vivo surgery and targeted drug delivery. However, research into applying microrobots inside non-Newtonian mucus environments has been limited. This paper seeks to demonstrate the swimming capabilities of microswimmer robots inside synthetic mucus. Microswimmer robots are composed of ferromagnetic beads linked together in a linear chain. The microswimmer can translate through the fluid medium of interest using rotating magnetic fields. Synthetic mucus was developed using dried mucin from a porcine stomach and mixed with deionized water in varying concentrations. These formulations were then analyzed using a rheometer to understand their rheological properties. Microswimmers were then inserted into these synthetic mucus formulations and were actuated at varying frequencies. The velocities of micro swimmers were extracted using computer vision techniques. Interestingly, microswimmers were able to swim in concentrations of mucin as high as 5%, however, at such a high concentration microswimmer performance was often inconsistent. Often, microswimmers not of the conventional three bead assembly performed much better than traditional three bead swimmers investigated in past research. These results indicate that smaller and less complicated swimmers can be used for in vivo usage.
影响因子：
3.4
作者：
Cheang UK;Ali J;Kim H;Rogowski L;Kim MJ
通讯作者：
Kim MJ
影响因子：
16.1
作者：
Lai, Samuel K.;Wang, Ying-Ying;Wirtz, Denis;Hanes, Justin
通讯作者：
Hanes, Justin