Micro- and macrorheology of mucus.
Micro- and macrorheology of mucus.
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DOI：
10.1016/j.addr.2008.09.012
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发表时间：
2009-02-27
影响因子：
16.1
通讯作者：
Hanes, Justin
中科院分区：
文献类型：
--
作者：
Lai, Samuel K.;Wang, Ying-Ying;Wirtz, Denis;Hanes, Justin
关键词：
粘液是一种复杂的生物材料，可以润滑和保护人体的肺部、胃肠道、阴道、眼睛和其他湿润的粘膜表面。粘液是一种物理屏障，可以抵御包括毒素、病原体和环境超细颗粒在内的外来颗粒，同时允许特定气体、离子、营养物质和许多蛋白质快速通过。它的选择性屏障特性在生物化学水平上被精确地调节，跨越了巨大的不同长度尺度。在宏观尺度上，黏液表现为非牛顿凝胶，其对剪切速率和剪切应力的响应区别于传统的固体和液体，而在纳米尺度上，黏液表现为低粘度流体。从宏观到纳米水平的黏液流变学表征的进展有助于对黏液生理学、疾病病理学和设计用于粘膜表面的药物递送系统的发展的关键理解。本文综述了控制黏液流变学的生物化学，人类和实验动物黏液的宏观和微观流变学，应用于黏液的流变学技术，以及提高对黏液物理性质的理解对推进药物和基因传递领域的重要性。
Mucus is a complex biological material that lubricates and protects the human lungs, gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as a physical barrier against foreign particles, including toxins, pathogens, and environmental ultrafine particles, while allowing rapid passage of selected gases, ions, nutrients, and many proteins. Its selective barrier properties are precisely regulated at the biochemical level across vastly different length scales. At the macroscale, mucus behaves as a non-Newtonian gel, distinguished from classical solids and liquids by its response to shear rate and shear stress, while, at the nanoscale, it behaves as a low viscosity fluid. Advances in the rheological characterization of mucus from the macroscopic to nanoscopic levels have contributed critical understanding to mucus physiology, disease pathology, and the development of drug delivery systems designed for use at mucosal surfaces. This article reviews the biochemistry that governs mucus rheology, the macro- and microrheology of human and laboratory animal mucus, rheological techniques applied to mucus, and the importance of an improved understanding of the physical properties of mucus to advancing the field of drug and gene delivery.
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影响因子：
9.4
作者：
BRISELDEN, AM;MONCLA, BJ;HILLIER, SL
通讯作者：
HILLIER, SL
影响因子：
3.3
作者：
BOUCHER, RC;STUTTS, MJ;GATZY, JT
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影响因子：
4.1
作者：
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影响因子：
5.5
作者：
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通讯作者：
YANKASKAS, JR
影响因子：
3.4
作者：
CHAO, CCW;VERGNES, JP;BROWN, SI
通讯作者：
BROWN, SI