Antenatal depressive symptoms and the risk of preeclampsia or operative deliveries: a meta-analysis.

Antenatal depressive symptoms and the risk of preeclampsia or operative deliveries: a meta-analysis.
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产前抑郁症状与先兆子痫或手术分娩的风险:荟萃分析

DOI:
10.1371/journal.pone.0119018
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发表时间:
2015
期刊:
影响因子:
3.7
通讯作者:
Yan W
Yan W
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Hu R;Li Y;Zhang Z;Yan W

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该研究的目的是调查妊娠期间抑郁和/或抑郁症状与手术分娩或先兆子痫风险之间的相关性,并量化相关性的强度。检索PubMed、SCI/SSCI、Proquest PsycARTICLES和CINAHL数据库,并通过手动检索关键检索文章和综述文章的参考书目进行补充。我们的目的是纳入病例对照或队列研究,这些研究报告了产前抑郁和/或抑郁症状以及手术分娩和/或先兆子痫风险的数据。12项自我报告筛选工具的研究符合纳入条件,共8400例受试者。包含4421名参与者的7篇文章报告了手术分娩的风险,包含3979名参与者的5篇文章报告了先兆子痫的风险。合并分析显示,手术分娩和先兆子痫与产前抑郁症状有统计学显著相关性(RR = 1.24; 95%CI,1.14 - 1.35; OR = 1.63,95%CI,1.32 - 2.02)。当孕前体重指数在其初始设计中得到控制时,先兆子痫的风险仍然存在(OR = 1.48,95% CI,1.04至2.01),而手术分娩的风险变得不确定(RR = 1.01,95% CI,0.85至1.22)。产后抑郁症状与手术分娩和先兆子痫的风险中度增加有关。一个异常的孕前体重指数可能会改变这种关联。
The purpose of the study was to investigate the association between depression and/or depressive symptoms during pregnancy and the risk of an operative delivery or preeclampsia, and to quantify the strength of the association. A search of the PubMed, SCI/SSCI, Proquest PsycARTICLES and CINAHL databases was supplemented by manual searches of bibliographies of key retrieved articles and review articles. We aimed to include case control or cohort studies that reported data on antenatal depression and /or depressive symptoms and the risk of an operative delivery and/or preeclampsia. Twelve studies with self-reported screening instruments were eligible for inclusion with a total of 8400 participants. Seven articles that contained 4421 total participants reported the risk for an operative delivery, and five articles that contained 3979 total participants reported the risk for preeclampsia. The pooled analyses showed that both operative delivery and preeclampsia had a statistically significant association with antenatal depressive symptoms (RR = 1.24; 95% CI, 1.14 to 1.35, and OR = 1.63, 95% CI, 1.32 to 2.02, respectively). When the pre-pregnancy body mass indices were controlled in their initial design, the risk for preeclampsia still existed (OR = 1.48, 95% CI, 1.04 to 2.01), while the risk for an operative delivery became uncertain (RR = 1.01, 95% CI, 0.85 to 1.22). Antenatal depressive symptoms are associated with a moderately increased risk of an operative delivery and preeclampsia. An abnormal pre-pregnancy body mass index may modify this association.
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