Blood oxygen level-dependent MR imaging of the kidneys.

Blood oxygen level-dependent MR imaging of the kidneys.
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DOI:
10.1016/j.mric.2008.07.008
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发表时间:
2008-11
影响因子:
1.6
通讯作者:
Prasad, Pottumarthi V.
Prasad, Pottumarthi V.
中科院分区:
医学4区
文献类型:
--
作者:
Li, Lu-Ping;Halter, Sarah;Prasad, Pottumarthi V.

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氧合状态在肾脏生理和病理生理中起着重要的作用,近年来引起了人们的广泛关注。虽然许多早期工作和大量目前的工作是基于侵入性方法或离体分析,因此仅限于动物模型,但BOLD(血氧水平依赖)MRI已被证明可以将这些发现扩展到人类。BOLD MRI在监测生理或药理学操作的效果方面最有用。世界各地的几个团队已经展示了可重复的数据,并说明了几个有用的应用。也有研究支持使用肾BOLD MRI来鉴别具有预后价值的疾病。在这里,概述了目前肾脏BOLD MRI的最新技术。
Oxygenation status plays a major role in renal physiology and pathophysiology and hence has attracted considerable attention in recent years. While much of the early work and a significant amount of present work is based on invasive methods or ex vivo analysis and hence restricted to animal models, BOLD (blood oxygen level dependent) MRI has been shown to extend these findings to humans. BOLD MRI is most useful in monitoring effects of physiological or pharmacological maneuvers. Several teams around the world have demonstrated reproducible data and have illustrated several useful applications. Studies supporting the use of renal BOLD MRI in characterizing disease with prognostic value have also been reported. Here, an overview of the current state-of-the art of renal BOLD MRI is provided.
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