Chromosome 1p and 19q evaluation in low-grade oligodendrogliomas: a descriptive study.
Chromosome 1p and 19q evaluation in low-grade oligodendrogliomas: a descriptive study.
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低级别少突胶质细胞瘤的染色体 1p 和 19q 评估：一项描述性研究。
DOI：
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发表时间：
2009
影响因子：
5.4
通讯作者：
D. Calistri
中科院分区：
文献类型：
--
作者：
C. Molinari;P. Iorio;L. Medri;M. Ballardini;G. Guiducci;A. Cremonini;S. Cerasoli;L. Riccioni;M. Faedi;G. A. Mariani;W. Zoli;R. Silvestrini;D. Calistri
少突胶质细胞瘤是一种罕见的原发性脑肿瘤，患者预后多变，临床或病理变量并不总是能充分解释。本研究评估了23例低级别少突胶质细胞瘤（OGD II）的1p和19q染色体状态对预后的影响，并将结果与患者预后相关联。使用了最广泛使用的标准程序杂合缺失（LOH）和荧光原位杂交（FISH）分析。FISH和LOH分别在65%和61%的病例和78%和72%的病例中发现1p和19q缺失。FISH和LOH分别在56%和64%的患者中发现这两种缺失。由Kappa统计确定的两种技术结果之间的一致性范围从公平到实质性取决于是否考虑了单个或组合缺失。我们的研究结果表明，分子改变与年龄和肿瘤定位有关。关于染色体改变对临床结果的影响，LOH检测到的染色体19q缺失似乎表明一个亚组患者复发风险较高，尽管招募的患者数量较少，无法得出任何明确的结论。目前正在进行进一步的研究，以确定这种方法学方法是否可能在低级别少突胶质细胞瘤中有用，以更好地表征1p/19q的染色体改变，并确定疾病复发风险较高的患者亚组。
Oligodendrogliomas are rare primary brain tumors with variable patient outcomes which are not always adequately accounted for by clinical or pathological variables. The present study evaluated the prognostic implications of chromosome 1p and 19q status in a set of 23 low grade oligodendrogliomas (OGD II), and correlated the results with patient outcome. Loss of heterozygosity (LOH) and fluorescent in situ hybridization (FISH) analyses, the most widely used standard procedures, were used. 1p and 19q deletions were found in 65 and 61% of cases, respectively, using FISH and in 78 and 72% of cases using LOH. Both deletions were found in 56 and 64% of patients using FISH and LOH, respectively. Concordance between the results from the two techniques, determined by the Kappa statistics, ranged from fair to substantial depending on whether single or combined deletions were considered. Our results showed that the molecular alterations are associated with age and tumor localization. With regard to the impact of chromosomal alterations on clinical outcome, chromosome 19q deletions detected by LOH would seem to indicate a subgroup of patients at a higher risk of relapse, although the small number of patients recruited does not permit any definitive conclusions to be drawn. Further studies are now ongoing to determine whether this methodological approach could be potentially useful in low grade oligodendrogliomas to better characterize chromosomal alterations of 1p/19q and identify subgroups of patients with a higher risk of disease recurrence.
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影响因子：
45.3
作者：
Press, MF;Slamon, DJ;Bernstein, L
通讯作者：
Bernstein, L
影响因子：
11.2
作者：
M. Zlatescu;Ali Reza TehraniYazdi;Hikaru Sasaki;Joseph F. Megyesi;R. Betensky;David N. Louis;J. Cairncross
通讯作者：
M. Zlatescu;Ali Reza TehraniYazdi;Hikaru Sasaki;Joseph F. Megyesi;R. Betensky;David N. Louis;J. Cairncross
DOI：
10.1093/jnci/90.19.1473
发表时间：
1998-10-07
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Cairncross, JG;Ueki, K;Louis, DN
通讯作者：
Louis, DN
影响因子：
45.3
作者：
Cairncross, Gregory;Berkey, Brian;Curran, Walter
通讯作者：
Curran, Walter
影响因子：
45.3
作者：
Smith, JS;Perry, A;Jenkins, RB
通讯作者：
Jenkins, RB