The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview.
The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview.
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DOI：
10.1016/j.biochi.2007.02.015
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发表时间：
2007-09
期刊：
影响因子：
3.9
通讯作者：
Boulay F
中科院分区：
文献类型：
--
作者：
Rabiet MJ;Huet E;Boulay F
白细胞向炎症和感染部位的募集依赖于局部产生的趋化因子梯度的存在。本文综述了趋化因子受体的激活和调控的最新研究进展。重点放在N-甲酰肽受体家族的成员上，即FPR（N-甲酰肽受体）、FPRL1（FPR样-1）和FPRL2（FPR样-2），以及补体片段C5a受体（C5aR和C5L2）。在化学引诱物结合后，受体通过G蛋白依赖性途径激活信号，导致有助于对细菌感染和组织损伤的生理防御的生化反应。C5aR和FPR家族的成员，以前被认为是局限于吞噬细胞证明有一个更广泛的细胞表达谱。除了N-甲酰化肽，最近发现许多不相关的配体与FPR和FPRL 1相互作用。新的激动剂包括病原体和宿主衍生的组分以及合成肽。已经鉴定出表现出有限受体特异性的拮抗分子。不同的配体如何既能诱导不同的生物反应，并产生不同的受体激活模式和独特的细胞反应集进行了讨论。细胞对化学引诱物的反应在受体水平上受到严格调控。本文详细介绍了受体信号的调节和受体失活的多步骤过程。新的概念，如受体寡聚化和受体集群，被认为是。尽管FPR、FPRL 1和C5aR触发相似的生物学功能并经历快速的趋化因子介导的磷酸化，但它们似乎受到差异调节并经历不同的细胞内命运。
Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of a gradient of locally produced chemotactic factors. This review is focused on current knowledge about the activation and regulation of chemoattractant receptors. Emphasis is placed on the members of the N-formyl peptide receptor family, namely FPR (N-formyl peptide receptor), FPRL1 (FPR like-1) and FPRL2 (FPR like-2), and the complement fragment C5a receptors (C5aR and C5L2). Upon chemoattractant binding, the receptors transduce an activation signal through a G protein-dependent pathway, leading to biochemical responses that contribute to physiological defense against bacterial infection and tissue damage. C5aR, and the members of the FPR family that were previously thought to be restricted to phagocytes proved to have a much broader spectrum of cell expression. In addition to N-formylated peptides, numerous unrelated ligands were recently found to interact with FPR and FPRL1. Novel agonists include both pathogen- and host-derived components, and synthetic peptides. Antagonistic molecules have been identified that exhibit limited receptor specificity. How distinct ligands can both induce different biological responses and produce different modes of receptor activation and unique sets of cellular responses are discussed. Cell responses to chemoattractants are tightly regulated at the level of the receptors. This review describes in detail the regulation of receptor signalling and the multi-step process of receptor inactivation. New concepts, such as receptor oligomerization and receptor clustering, are considered. Although FPR, FPRL1 and C5aR trigger similar biological functions and undergo a rapid chemoattractant-mediated phosphorylation, they appear to be differentially regulated and experience different intracellular fates.
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DOI：
10.1016/0006-291x(90)91143-g
发表时间：
1990-05-16
影响因子：
3.1
作者：
BOULAY, F;TARDIF, M;VIGNAIS, P
通讯作者：
VIGNAIS, P
影响因子：
4.4
作者：
Bae, YS;Yi, HJ;Ryu, SH
通讯作者：
Ryu, SH
影响因子：
4.8
作者：
Cain, SA;Monk, PN
通讯作者：
Monk, PN
影响因子：
2.9
作者：
BOULAY, F;MERY, L;VIGNAIS, P
通讯作者：
VIGNAIS, P
影响因子：
64.8
作者：
CAMPS, M;CAROZZI, A;GIERSCHIK, P
通讯作者：
GIERSCHIK, P