Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators.
Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators.
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DOI：
10.4049/jimmunol.1100150
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发表时间：
2011-10-01
期刊：
影响因子：
--
通讯作者：
Colgan SP
中科院分区：
文献类型：
--
作者：
Campbell EL;Serhan CN;Colgan SP
粘液表面作为宿主与外界之间的选择性渗透屏障。由于它们与微生物抗原非常接近，粘膜表面已经进化出复杂的机制来维持体内平衡和防止过度的急性炎症反应。上皮细胞的作用历来仅限于作为一种选择性屏障，近年来，许多研究结果表明，上皮细胞在维持免疫平衡中发挥着积极的作用。在这篇简短的综述中，我们强调了新的证据，即上皮细胞积极促进炎症的协调和解决，主要是通过产生抗炎和促解决脂质介质。这些来自ω-6和ω-3多不饱和脂肪酸的自泌素参与急性炎症的发生、发展和消退，并显示出特异性的、上皮定向的作用，重点是粘膜稳态。我们还总结了目前的知识，通过调节上皮来源的抗菌肽在响应亲解决脂质介质的解决机制。
Mucosal surfaces function as selectively permeable barriers between the host and the outside world. Given their close proximity to microbial antigens, mucosal surfaces have evolved sophisticated mechanisms for maintaining homeostasis and preventing excessive acute inflammatory reactions. The role attributed to epithelial cells was historically limited to serving as a selective barrier, in recent years numerous findings implicate an active role of the epithelium with pro-resolving mediators in the maintenance of immunological equilibrium. In this brief review, we highlight new evidence that the epithelium actively contributes to coordination and resolution of inflammation, principally through the generation of anti-inflammatory and pro-resolution lipid mediators. These autacoids, derived from ω-6 and ω-3 polyunsaturated fatty acids, are implicated in the initiation, progression and resolution of acute inflammation and display specific, epithelial-directed actions focused on mucosalhomeostasis. We also summarize present knowledge of mechanisms for resolution via regulation of epithelial-derived antimicrobial peptides in response to pro-resolving lipid mediators.
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DOI：
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发表时间：
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期刊：
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影响因子：
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