Examination of chemosensory functions in patients with dysosmia.
Examination of chemosensory functions in patients with dysosmia.
复制标题
嗅觉障碍患者化学感觉功能的检查。
DOI：
10.12659/msm.882520
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Yang L;Wei Y;Zhang W;Yu D;Ren Y;Li K;Guo Y;Zhang J
观察嗅觉障碍患者化学感觉功能的变化。272名研究受试者包括98名健康志愿者、86名嗅觉减退受试者和88名功能性嗅觉丧失受试者。分别采用嗅觉事件相关电位（oERPs）、三叉神经事件相关电位（tERPs）、T&T嗅觉仪和三滴法检测化学感觉功能。T&T结果显示，患者与健康人之间的差异有统计学意义。oERPs和tERPs结果显示，功能性嗅觉丧失患者的N1和P2波潜伏期延长，波幅降低，与正常对照组比较差异有统计学意义。功能性嗅觉丧失患者与健康人相比，有明显的味觉减退，差异有统计学意义。在青年组中，正常人与患者的T&T、oERPs和tERPs结果有显著性差异。功能性嗅觉丧失患者明显伴有三叉神经功能障碍和味觉减退，提示青年患者嗅觉和鼻三叉神经功能明显下降。本研究提示oERPs、tERPs和三滴法在中国人群中可能应用于临床诊断，并为治疗提供科学依据。
To examine changes of chemical sensory functions in patients with dysosmia. The 272 study subjects included 98 healthy volunteers, 86 subjects with hyposmia and 88 subjects with functional anosmia. Their chemical sensory functions were examined using olfactory event-related potentials (oERPs), trigeminal event-related potentials (tERPs), T&T olfactometer and triple drop method, respectively. The T&T results showed that the difference between patients and healthy subjects had statistical significance. The oERPs and tERPs results showed that patients with functional anosmia had N1 and P2 waves of prolonged latency and reduced amplitude when compared to healthy subjects with the difference of statistical significance. When compared to healthy subjects, patients with functional anosmia had clear hypogeusia and the difference had statistical significance. For the younger group there was significant difference between healthy subjects and patients in T&T, oERPs and tERPs results. It is suggested by the apparently concomitant trigeminal nerve dysfunction and hypogeusia in patients with functional anosmia in this study that olfactory and nasal trigeminal function in young patients was clearly decreased. Our study suggests the possible application of oERPs, tERPs and three drops method in clinical diagnosis in Chinese populations and provides scientific evidence for treatment.
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