Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults.
Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults.
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DOI：
10.1007/s00223-008-9197-3
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发表时间：
2009-02
影响因子：
4.2
通讯作者：
Mitchell, Braxton D.
中科院分区：
文献类型：
--
作者：
Shaffer, John R.;Kammerer, Candace M.;Bruder, Jan M.;Cole, Shelley A.;Dyer, Thomas D.;Almasy, Laura;MacCluer, Jean W.;Blangero, John;Bauer, Richard L.;Mitchell, Braxton D.
骨丢失早在第三个十年就发生了，其在整个成年期的累积效应可能会影响晚年骨质疏松的风险，但影响早期骨丢失的基因和环境因素在很大程度上是未知的。我们调查了圣安东尼奥家族骨质疏松症研究参与者骨密度(BMD)变化中基因的作用。对32个家系中的327名墨西哥裔美国人(年龄25-45岁)的骨密度变化进行了基线和随访(3.5-8.9年后)的DXA测量。用基于家族的似然法估计遗传度(H2)，对股骨和前臂近端骨密度变化进行常染色体连锁分析，对腰椎骨密度变化进行遗传度估计。骨密度改变在全髋关节、超远端桡骨和33%桡骨中有显著的遗传性(h2=0.34、0.34、0.27，p<；0.03)，股骨颈有轻度遗传性(h2=0.22，p=0.06)，脊柱骨密度没有遗传性。与BMD变化相关的协变量包括年龄、性别、基线BMD、绝经、体重指数和临时BMI变化，并解释了表型变化的6%至24%。在染色体1q23上观察到一个显著的影响股骨颈骨密度变化的数量性状基因座(LOD=3.6)。我们观察到，年轻人的骨密度变化是可遗传的，并进行了第一批骨密度变化的连锁研究之一。与染色体1q23的连锁表明，该区域可能包含一个或多个参与调节股骨颈早期骨密度变化的基因。
Bone loss occurs as early as the third decade and its cumulative effect throughout adulthood may impact risk for osteoporosis in later life, however the genes and environmental factors influencing early bone loss are largely unknown. We investigated the role of genes in the change in bone mineral density (BMD) in participants of the San Antonio Family Osteoporosis Study. BMD change in 327 Mexican Americans (ages 25–45 years) from 32 extended pedigrees was calculated from DXA measurements at baseline and follow-up (3.5 to 8.9 years later). Family-based likelihood methods were used to estimate heritability (h2) and perform autosome-wide linkage analysis for BMD change of the proximal femur and forearm, and estimate heritability for BMD change of lumbar spine. BMD change was significantly heritable for total hip, ultradistal radius and 33% radius (h2 = 0.34, 0.34, 0.27, respectively, p < 0.03 for all), modestly heritable for femoral neck (h2 = 0.22, p = 0.06) and not heritable for spine BMD. Covariates associated with BMD change included age, sex, baseline BMD, menopause, body mass index, and interim BMI change, and accounted for 6% to 24% of phenotype variation. A significant quantitative trait locus (LOD = 3.6) for femoral neck BMD change was observed on chromosome 1q23. We observed that change in BMD in young adults is heritable, and performed one of the first linkage studies for BMD change. Linkage to chromosome 1q23 suggests this region may harbor one or more genes involved in regulating early BMD change of the femoral neck.
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影响因子：
5.8
作者：
Bustamante, M.;Nogues, X.;Balcells, S.
通讯作者：
Balcells, S.
影响因子：
4.1
作者：
Karasik, D;Cupples, LA;Kiel, DP
通讯作者：
Kiel, DP
影响因子：
2.1
作者：
Blangero, J;Williams, JT;Almasy, L
通讯作者：
Almasy, L
影响因子：
3.5
作者：
Devoto, M;Specchia, C;Spotila, LD
通讯作者：
Spotila, LD
影响因子：
6.2
作者：
Hui, SL;Koller, DL;Peacock, M
通讯作者：
Peacock, M