Practice-related changes in neural activation patterns investigated via wavelet-based clustering analysis.
Practice-related changes in neural activation patterns investigated via wavelet-based clustering analysis.
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DOI：
10.1002/hbm.22066
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发表时间：
2013-09
影响因子：
4.8
通讯作者：
McDowell, Jennifer E.
中科院分区：
文献类型：
--
作者：
Lee, Jinae;Park, Cheolwoo;Dyckman, Kara A.;Lazar, Nicole A.;Austin, Benjamin P.;Li, Qingyang;McDowell, Jennifer E.
使用功能磁共振成像（fMRI）评估大脑激活，特别是在眼动任务期间与实践相关的认知控制相关的激活随时间的变化。参与者进行反眼跳表演（从提示处扫一眼），同时在两个不同的时间点获取 fMR 图像：1）在任何暴露于任务之前的预测试，2）在测试后，每天进行反眼跳、前眼跳（扫视目标）或注视（保持注视目标）练习一周后。对三个练习组在两个时间点进行比较，并通过应用基于小波分析的无模型聚类技术进行分析。这一系列程序的开发是为了避免 fMRI 数据固有的分析问题，由几个步骤组成：去趋势、数据聚合、小波变换和阈值、无趋势检验、主成分分析和 K 均值聚类。主要的聚类算法是在小波域中构建的，以考虑时间相关性。我们应用基于小波的无趋势检验来显着降低数据的高维。我们使用主成分分析 K 均值聚类对剩余体素的阈值小波系数进行聚类。在一系列的分析中，我们发现，反眼跳练习组是唯一一个从测试前到测试后眼跳回路激活减少的组，特别是在辅助眼野、额眼野、上顶叶和楔叶中明显。
To evaluate brain activation using functional magnetic resonance imaging (fMRI) and specifically, activation changes across time associated with practice-related cognitive control during eye movement tasks. Participants were engaged in antisaccade performance (generating a glance away from a cue) while fMR images were acquired during two separate time points: 1) at pre-test before any exposure to the task, and 2) at post-test, after one week of daily practice on antisaccades, prosaccades (glancing towards a target) or fixation (maintaining gaze on a target). The three practice groups were compared across the two time points, and analyses were conducted via the application of a model-free clustering technique based on wavelet analysis. This series of procedures was developed to avoid analysis problems inherent in fMRI data and was composed of several steps: detrending, data aggregation, wavelet transform and thresholding, no trend test, principal component analysis and K-means clustering. The main clustering algorithm was built in the wavelet domain to account for temporal correlation. We applied a no trend test based on wavelets to significantly reduce the high dimension of the data. We clustered the thresholded wavelet coefficients of the remaining voxels using the principal component analysis K-means clustering. Over the series of analyses, we found that the antisaccade practice group was the only group to show decreased activation from pre- to post-test in saccadic circuitry, particularly evident in supplementary eye field, frontal eye fields, superior parietal lobe, and cuneus.
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影响因子：
4.5
作者：
Genovese, CR;Wasserman, L
通讯作者：
Wasserman, L
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Gautama, T;Van Hulle, MM
通讯作者：
Van Hulle, MM
影响因子：
5.7
作者：
Dyckman, Kara A.;Camchong, Jazmin;McDowell, Jennifer E.
通讯作者：
McDowell, Jennifer E.