The use of an automated, portable glucose control system for overnight glucose control in adolescents and young adults with type 1 diabetes.
The use of an automated, portable glucose control system for overnight glucose control in adolescents and young adults with type 1 diabetes.
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DOI：
10.2337/dc12-0761
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发表时间：
2012-11
期刊：
影响因子：
16.2
通讯作者：
Ly TT
中科院分区：
文献类型：
--
作者：
O'Grady MJ;Retterath AJ;Keenan DB;Kurtz N;Cantwell M;Spital G;Kremliovsky MN;Roy A;Davis EA;Jones TW;Ly TT
为门诊患者提供有效安全的闭环人工胰腺系统的一个关键里程碑是开发具有故障检测功能的全自动便携式设备，以确保患者安全。远程监控闭环系统运行的能力将促进未来医生监督的家庭研究。本研究旨在研究全自动便携式闭环系统的有效性和安全性。Medtronic便携式血糖控制系统（PGCS）由两个皮下葡萄糖传感器、基于比例积分微分的控制算法（通过BlackBerry Storm智能手机平台进行胰岛素反馈）、蓝牙射频转换器和现成的Medtronic Paradigm Veo胰岛素泵组成。使用胰岛素泵治疗的1型糖尿病参与者在基线开环评估后连续两晚进行门诊、过夜、闭环控制。8名参与者参加了16项通宵研究。PGCS维持平均过夜血糖水平为6.4 ± 1.7 mmol/L（115 ± 31 mg/dL）。静脉血糖<3.9、3.9 - 8（70 - 144 mg/dL）和>8 mmol/L的时间比例分别为7%、78%和15%。闭环探头葡萄糖值维持在3.9和8 mmol/L之间的时间比例大于开环（84.5 vs. 46.7%; P < 0.0001），<3.3 mmol/L的时间也减少（0.9 vs. 3%; P < 0.0001）。这些结果表明，PGCS是一种自动闭环装置，可安全有效地实现1型糖尿病患者的夜间血糖控制。
A key milestone in progress towards providing an efficacious and safe closed-loop artificial pancreas system for outpatient use is the development of fully automated, portable devices with fault detection capabilities to ensure patient safety. The ability to remotely monitor the operation of the closed-loop system would facilitate future physician-supervised home studies. This study was designed to investigate the efficacy and safety of a fully automated, portable, closed-loop system. The Medtronic Portable Glucose Control System (PGCS) consists of two subcutaneous glucose sensors, a control algorithm based on proportional-integral-derivative with insulin feedback operating from a BlackBerry Storm smartphone platform, Bluetooth radiofrequency translator, and an off-the-shelf Medtronic Paradigm Veo insulin pump. Participants with type 1 diabetes using insulin pump therapy underwent two consecutive nights of in-clinic, overnight, closed-loop control after a baseline open-loop assessment. Eight participants attended for 16 overnight studies. The PGCS maintained mean overnight plasma glucose levels of 6.4 ± 1.7 mmol/L (115 ± 31 mg/dL). The proportion of time with venous plasma glucose <3.9, between 3.9 and 8 (70 and 144 mg/dL), and >8 mmol/L was 7, 78, and 15%, respectively. The proportion of time the sensor glucose values were maintained between 3.9 and 8 mmol/L was greater for closed-loop than open-loop (84.5 vs. 46.7%; P < 0.0001), and time spent <3.3 mmol/L was also reduced (0.9 vs. 3%; P < 0.0001). These results suggest that the PGCS, an automated closed-loop device, is safe and effective in achieving overnight glucose control in patients with type 1 diabetes.
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影响因子：
16.2
作者：
Atlas E;Nimri R;Miller S;Grunberg EA;Phillip M
通讯作者：
Phillip M
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16.2
作者：
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158.5
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