Animal Models of Exercise From Rodents to Pythons.
Animal Models of Exercise From Rodents to Pythons.
复制标题
从啮齿动物到蟒蛇的动物模型。
DOI：
10.1161/circresaha.122.320247
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发表时间：
2022-06-10
影响因子：
20.1
通讯作者：
Rosenzweig, Anthony
中科院分区：
文献类型：
--
作者：
Hastings, Margaret H.;Herrera, Jonathan J.;Guseh, J. Sawalla;Atlason, Bjarni;Houstis, Nicholas E.;Abdul Kadir, Azrul;Li, Haobo;Sheffield, Cedric;Singh, Anand P.;Roh, Jason D.;Day, Sharlene M.;Rosenzweig, Anthony
急性和慢性运动动物模型在研究中是常用的。急性运动试验通常与遗传学、药理学或其他方法结合使用，以研究这些方法对心血管运动反应的影响，并检测心血管功能的损伤或改善，这些损伤或改善在静止时可能不明显。慢性运动调节模型用于研究心脏对定期运动训练的表型反应，并作为发现运动调节所带来的心血管益处的新途径的平台，这些途径可以用于治疗。运动对心血管的益处已经得到了很好的证实，通常，模仿运动引起的通路变化的分子操作至少概括了运动的一些益处。这篇综述讨论了评估啮齿动物急性运动挑战期间心血管功能的方法，以及在使用常见啮齿动物运动调节模型时的实际和概念考虑。研究喂食的情况下，缅甸蟒蛇作为一个模型的运动类生理适应也进行了探讨。
Acute and chronic animal models of exercise are commonly used in research. Acute exercise testing is used, often in combination with genetic, pharmacological or other manipulations, to study the impact of these manipulations on the cardiovascular response to exercise and to detect impairments or improvements in cardiovascular function that may not be evident at rest. Chronic exercise conditioning models are used to study the cardiac phenotypic response to regular exercise training, and as a platform for discovery of novel pathways mediating cardiovascular benefits conferred by exercise conditioning that could be exploited therapeutically. The cardiovascular benefits of exercise are well established and, frequently, molecular manipulations that mimic the pathway changes induced by exercise recapitulate at least some of its benefits. This review discusses approaches for assessing cardiovascular function during an acute exercise challenge in rodents, as well as practical and conceptual considerations in the use of common rodent exercise conditioning models. The case for studying feeding in the Burmese python as a model for exercise-like physiological adaptation is also explored.
影响因子：
3.7
作者：
Johnsen AB;Høydal M;Røsbjørgen R;Stølen T;Wisløff U
通讯作者：
Wisløff U