Clinical predictors of outcome in patients with inflammatory dilated cardiomyopathy.
Clinical predictors of outcome in patients with inflammatory dilated cardiomyopathy.
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DOI：
10.1371/journal.pone.0188491
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Pankuweit S
中科院分区：
文献类型：
--
作者：
Karatolios K;Holzendorf V;Hatzis G;Tousoulis D;Richter A;Schieffer B;Pankuweit S
本研究的目的是确定炎症性扩张型心肌病（DCMi）患者预后的预测因素。从2004年到2008年，确定了55例活检证实的DCMi患者，并随访了58.2±19.8个月。结果的预测因素通过多变量分析和考克斯比例风险分析确定。主要终点是死亡、心脏移植和因心力衰竭或室性心律失常住院的复合终点。对于主要终点，QTc间期> 440 msec（HR 2.84; 95% CI 1.03-7.87; p = 0.044），肾小球滤过率（GFR）<60 ml/min/1.73 m2（HR 3.19; 95% CI 1.35-7.51; p = 0.008）和随访期间NYHA分级恶化（HR 2.48; 95% CI 1.01-6.10; p = 0.048）是单变量预测因子，而基线时的左心室射血分数、入组时的NYHA分级、房颤，洋地黄治疗或病毒基因组检测与结果无显著相关性。多变量分析后，GFR <60 ml/min/1.73 m2（HR 3.04; 95% CI 1.21-7.66; p = 0.018）仍然是不良结局的预测因子。在DCMi患者中，QTc间期延长> 440 msec、GFR<60 ml/min/1.73 m2和随访期间NYHA分级恶化是不良预后的单变量预测因素。相比之下，基线NYHA分级、左心室射血分数、房颤、洋地黄治疗或病毒基因组检测与结局无关。多变量分析后，GFR <60 ml/min/1.73m2仍与不良结局独立相关。
The study objectives were to identify predictors of outcome in patients with inflammatory dilated cardiomyopathy (DCMi). From 2004 to 2008, 55 patients with biopsy-proven DCMi were identified and followed up for 58.2±19.8 months. Predictors of outcome were identified in a multivariable analysis with a Cox proportional hazards analysis. The primary endpoint was a composite of death, heart transplantation and hospitalization for heart failure or ventricular arrhythmias. For the primary endpoint, a QTc interval >440msec (HR 2.84; 95% CI 1.03–7.87; p = 0.044), a glomerular filtration rate (GFR) <60ml/min/1.73m2 (HR 3.19; 95% CI 1.35–7.51; p = 0.008) and worsening of NYHA classification during follow-up (HR 2.48; 95% CI 1.01–6.10; p = 0.048) were univariate predictors, whereas left ventricular ejection fraction at baseline, NYHA class at entry, atrial fibrillation, treatment with digitalis or viral genome detection were not significantly related to outcome. After multivariable analysis, a GFR <60ml/min/1.73m2 (HR 3.04; 95% CI 1.21–7.66; p = 0.018) remained a predictor of adverse outcome. In patients with DCMi, a prolonged QTc interval >440msec, a GFR<60ml/min/1.73m2 and worsening of NYHA classification during follow-up were univariate predictors of adverse prognosis. In contrast, NYHA classification at baseline, left ventricular ejection fraction, atrial fibrillation, treatment with digitalis or viral genome detection were not related to outcome. After multivariable analysis, a GFR <60ml/min/1.73m2 remained independently associated with adverse outcome.
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影响因子：
37.8
作者：
Kühl, U;Pauschinger, M;Schultheiss, HPP
通讯作者：
Schultheiss, HPP
影响因子：
24
作者：
Olsson, Lars G.;Swedberg, Karl;Pfeffer, Marc A.
通讯作者：
Pfeffer, Marc A.
影响因子：
24
作者：
Kindermann, Ingrid;Barth, Christine;Boehm, Michael
通讯作者：
Boehm, Michael
影响因子：
39.3
作者：
Brooksby, P;Batin, PD;Fox, KAA
通讯作者：
Fox, KAA
DOI：
10.1056/nejmra0800028
发表时间：
2009-04-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cooper LT Jr
通讯作者：
Cooper LT Jr