West Nile virus epidemics in North America are driven by shifts in mosquito feeding behavior.
West Nile virus epidemics in North America are driven by shifts in mosquito feeding behavior.
复制标题
DOI：
10.1371/journal.pbio.0040082
复制
发表时间：
2006-04
期刊：
影响因子：
9.8
通讯作者：
Daszak P
中科院分区：
文献类型：
--
作者：
Kilpatrick AM;Kramer LD;Jones MJ;Marra PP;Daszak P
西尼罗河病毒（WNV）自1999年首次发现以来，已在北美多次引起大规模人类流行病，目前已成为该大陆主要的媒介传播疾病。了解决定这种人畜共患病原体从鸟类到人类（通过蚊子）的溢出强度的因素是预测和预防人类流行病的先决条件。我们将蚊子的摄食行为与蚊子、鸟类和人类的种群动态和西尼罗河病毒流行病学数据相结合。我们发现，在美国东北部和中北部城市化地区，淡色库蚊是西尼罗河病毒的主要地方性（鸟对鸟）和桥梁（鸟对人）媒介，在夏末和初秋期间，其摄食偏好从鸟类转向人类，增加了 7 倍，这与其首选宿主（美洲知更鸟、迁徙鸫）的扩散和人类西尼罗河病毒感染的增加同时发生。我们还表明 Cx 的喂养变化。跗螈会加剧科罗拉多州和加利福尼亚州人类西尼罗河病毒的流行，并发生在知更鸟扩散和迁徙期间。我们的研究结果为人类西尼罗河病毒流行的时间和强度提供了直接的解释。在蚊子感染流行率很高之后，在流行病早期将食物从有能力的鸟类宿主转移到无能力的人类，会产生协同效应，大大增加了这种病原体和其他病原体的人类感染数量。我们的结果强调了媒介行为在推动人畜共患病原体向人类传播方面的巨大影响。 夏末蚊子的摄食行为从鸟类转向哺乳动物，增加了美国东北部和中北部人类感染西尼罗河病毒的数量。
West Nile virus (WNV) has caused repeated large-scale human epidemics in North America since it was first detected in 1999 and is now the dominant vector-borne disease in this continent. Understanding the factors that determine the intensity of the spillover of this zoonotic pathogen from birds to humans (via mosquitoes) is a prerequisite for predicting and preventing human epidemics. We integrated mosquito feeding behavior with data on the population dynamics and WNV epidemiology of mosquitoes, birds, and humans. We show that Culex pipiens, the dominant enzootic (bird-to-bird) and bridge (bird-to-human) vector of WNV in urbanized areas in the northeast and north-central United States, shifted its feeding preferences from birds to humans by 7-fold during late summer and early fall, coinciding with the dispersal of its preferred host (American robins, Turdus migratorius) and the rise in human WNV infections. We also show that feeding shifts in Cx. tarsalis amplify human WNV epidemics in Colorado and California and occur during periods of robin dispersal and migration. Our results provide a direct explanation for the timing and intensity of human WNV epidemics. Shifts in feeding from competent avian hosts early in an epidemic to incompetent humans after mosquito infection prevalences are high result in synergistic effects that greatly amplify the number of human infections of this and other pathogens. Our results underscore the dramatic effects of vector behavior in driving the transmission of zoonotic pathogens to humans. A shift in the feeding behavior of mosquitoes from birds to mammals in late summer amplifies the number of human infections of West Nile virus in the northeast and north-central US.
登录
查看更多内容
影响因子：
56.9
作者：
Fonseca, DM;Keyghobadi, N;Wilkerson, RC
通讯作者：
Wilkerson, RC
DOI：
10.4269/ajtmh.1995.53.105
发表时间：
1995-07-01
影响因子：
3.3
作者：
CRABTREE, MB;SAVAGE, HM;MILLER, BR
通讯作者：
MILLER, BR
DOI：
10.4269/ajtmh.2003.69.141
发表时间：
2003-08-01
影响因子：
3.3
作者：
Blackmore, CGM;Stark, LM;Wiersma, ST
通讯作者：
Wiersma, ST
影响因子：
5.9
作者：
Griffis-Kyle, KL;Beier, P
通讯作者：
Beier, P
影响因子：
9.4
作者：
Kauffman, EB;Jones, SA;Kramer, LD
通讯作者：
Kramer, LD