Neurotensin pathway in digestive cancers and clinical applications: an overview.
Neurotensin pathway in digestive cancers and clinical applications: an overview.
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消化癌和临床应用中的神经素途径：概述。
DOI：
10.1038/s41419-020-03245-8
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发表时间：
2020-12-02
影响因子：
9
通讯作者：
Perraud A
中科院分区：
文献类型：
--
作者：
Christou N;Blondy S;David V;Verdier M;Lalloué F;Jauberteau MO;Mathonnet M;Perraud A
最初，神经降压素（NTS）已被证明在中枢神经系统中作为神经递质/调节剂和在外周中作为内分泌因子发挥生理和生物学功能，通过其与两种受体结合：NTSR 1和2（G蛋白偶联受体）和NTSR 3/分拣蛋白（空泡蛋白分选10结构域受体）。NTS还在许多类型的癌症中发挥致癌作用，包括消化道癌症。在肿瘤组织中，NTS和NTSR 1的表达高于健康组织，并且与不良预后相关。NTS和NTRS 1促进癌症进展，并在转移过程中发挥关键作用;它们调节几种信号通路，并有助于肿瘤微环境的变化。相反，NTRS 2参与消化道癌症的了解甚少。分拣蛋白被发现介导NTS生物学效应，最近成为一个有前途的目标，因为它的表达被发现在各种类型的癌症中增加。由于它可以分泌，可溶性形式的分拣蛋白（sSortilin）作为一种新的血清生物标志物出现，在最近的研究的基础上，有望在诊断和肿瘤进展监测中发挥作用。更确切地说，似乎可溶性分拣蛋白可以与其他受体如TRKB相关。这些关联发生在外泌体中，并引发恶性胶质瘤等癌症的侵袭性，从而产生了可能的复合治疗诊断生物标志物的概念。本文综述了NTS信号通路在消化道肿瘤中的致癌作用，并讨论了它们作为有前途的早期诊断和/或预后生物标志物和治疗靶点的出现。
Initially, NEUROTENSIN (NTS) has been shown to play physiological and biological functions as a neuro-transmitter/modulator in the central nervous system and as an endocrine factor in the periphery, through its binding to two kinds of receptors: NTSR1 and 2 (G protein-coupled receptors) and NTSR3/sortilin (a vacuolar protein-sorting 10-domain receptor). NTS also plays oncogenic roles in many types of cancer, including digestive cancers. In tumor tissues, NTS and NTSR1 expression is higher than in healthy ones and is associated with poor prognosis. NTS and NTRS1 promote cancer progression and play key functions in metastatic processes; they modulate several signaling pathways and they contribute to changes in the tumor microenvironment. Conversely, NTRS2 involvement in digestive cancers is poorly understood. Discovered for mediating NTS biological effects, sortilin recently emerged as a promising target as its expression was found to be increased in various types of cancers. Because it can be secreted, a soluble form of sortilin (sSortilin) appears as a new serum biomarker which, on the basis of recent studies, promises to be useful in both the diagnosis and tumor progression monitoring. More precisely, it appears that soluble sortilin can be associated with other receptors like TRKB. These associations occur in exosomes and trigger the aggressiveness of cancers like glioblastoma, leading to the concept of a possible composite theranostic biomarker. This review summarizes the oncogenic roles of the NTS signaling pathways in digestive cancers and discusses their emergence as promising early diagnostic and/or prognostic biomarkers and therapeutic targets.
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影响因子：
6.8
作者：
Cathcart, Jillian;Pulkoski-Gross, Ashleigh;Cao, Jian
通讯作者：
Cao, Jian
影响因子：
6.4
作者：
Bugni, James M.;Al-Rabadi, Leina;Pothoulakis, Charalabos
通讯作者：
Pothoulakis, Charalabos
影响因子：
6.4
作者：
Dal Farra, C;Sarret, P;Vincent, JP
通讯作者：
Vincent, JP
DOI：
10.1006/bbrc.2000.2335
发表时间：
2000-03-24
影响因子：
3.1
作者：
Ehlers, RA;Zhang, YJ;Evers, BM
通讯作者：
Evers, BM
影响因子：
3.7
作者：
Dupouy, Sandra;Viardot-Foucault, Veronique;Alifano, Marco;Souaze, Frederique;Plu-Bureau, Genevieve;Chaouat, Marc;Lavaur, Anne;Hugol, Danielle;Gespach, Christian;Gompel, Anne;Forgez, Patricia
通讯作者：
Forgez, Patricia