Crosstalk Between the Gut Microbiota and Epithelial Cells Under Physiological and Infectious Conditions.
Crosstalk Between the Gut Microbiota and Epithelial Cells Under Physiological and Infectious Conditions.
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生理和感染条件下肠道微生物群和上皮细胞之间的串扰
DOI：
10.3389/fcimb.2022.832672
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发表时间：
2022
影响因子：
5.7
通讯作者：
Tang B
中科院分区：
文献类型：
--
作者：
Zhou A;Yuan Y;Yang M;Huang Y;Li X;Li S;Yang S;Tang B
胃肠道（GIT）被认为是最大的免疫器官，具有多样化的肠道微生物群，有助于对抗病原体和维护人类健康。在生理条件下，肠道微生物群和肠上皮细胞（IEC）之间的串扰在GIT稳态中起着至关重要的作用。肠道微生物群和衍生的代谢物可以通过激活IEC中的一些信号通路来损害肠道屏障的完整性。相反，IEC可以将肠道微生物群与宿主免疫细胞分离，以避免过度的免疫反应，并通过提供替代能源和释放一些分子（如激素和粘液）来调节肠道微生物群的组成。各种病原体（如细菌、病毒和寄生虫）的感染会扰乱肠道微生物群的多样性，并影响IEC的结构和代谢。然而，感染期间肠道微生物群和IEC之间的相互作用仍然不清楚。在这篇综述中，我们将集中在现有的证据来阐明肠道微生物群和IEC之间的串扰在感染和讨论一些潜在的治疗方法，包括益生菌，粪便微生物群移植（FMT），和膳食纤维。了解串扰在感染过程中的作用可能有助于我们建立预防和治疗感染性疾病患者的新策略，如C。艰难梭菌感染艾滋病和新冠肺炎
The gastrointestinal tract (GIT) is considered the largest immunological organ, with a diverse gut microbiota, that contributes to combatting pathogens and maintaining human health. Under physiological conditions, the crosstalk between gut microbiota and intestinal epithelial cells (IECs) plays a crucial role in GIT homeostasis. Gut microbiota and derived metabolites can compromise gut barrier integrity by activating some signaling pathways in IECs. Conversely, IECs can separate the gut microbiota from the host immune cells to avoid an excessive immune response and regulate the composition of the gut microbiota by providing an alternative energy source and releasing some molecules, such as hormones and mucus. Infections by various pathogens, such as bacteria, viruses, and parasites, can disturb the diversity of the gut microbiota and influence the structure and metabolism of IECs. However, the interaction between gut microbiota and IECs during infection is still not clear. In this review, we will focus on the existing evidence to elucidate the crosstalk between gut microbiota and IECs during infection and discuss some potential therapeutic methods, including probiotics, fecal microbiota transplantation (FMT), and dietary fiber. Understanding the role of crosstalk during infection may help us to establish novel strategies for prevention and treatment in patients with infectious diseases, such as C. difficile infection, HIV, and COVID-19.
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影响因子：
17.1
作者：
Chen K;Zhu Y;Zhang Y;Hamza T;Yu H;Saint Fleur A;Galen J;Yang Z;Feng H
通讯作者：
Feng H
DOI：
10.1016/j.jcmgh.2020.11.011
发表时间：
2021
影响因子：
7.2
作者：
Bilotta AJ;Ma C;Yang W;Yu Y;Yu Y;Zhao X;Zhou Z;Yao S;Dann SM;Cong Y
通讯作者：
Cong Y
影响因子：
30.3
作者：
Burger E;Araujo A;López-Yglesias A;Rajala MW;Geng L;Levine B;Hooper LV;Burstein E;Yarovinsky F
通讯作者：
Yarovinsky F
影响因子：
9.3
作者：
Deschasaux-Tanguy M;Srour B;Bourhis L;Arnault N;Druesne-Pecollo N;Esseddik Y;de Edelenyi FS;Allègre J;Allès B;Andreeva VA;Baudry J;Fezeu LK;Galan P;Julia C;Kesse-Guyot E;Péneau S;Hercberg S;Bajos N;Severi G;Zins M;de Lamballerie X;Carrat F;Touvier M;SAPRIS-SERO study group
通讯作者：
SAPRIS-SERO study group
影响因子：
29.4
作者：
Alemi F;Poole DP;Chiu J;Schoonjans K;Cattaruzza F;Grider JR;Bunnett NW;Corvera CU
通讯作者：
Corvera CU