Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine.
Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine.
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DOI：
10.1016/j.progpolymsci.2013.12.001
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发表时间：
2014-07
影响因子：
27.1
通讯作者：
Alsberg E
中科院分区：
文献类型：
--
作者：
Nguyen MK;Alsberg E
聚合物水凝胶因其具有缓释、定位和控释生物活性因子的能力而被广泛研究作为治疗载体。由可注射生物聚合物水凝胶提供的生物活性因子提供了一种治疗多种疾病、指导细胞功能和增强组织再生的通用方法。天然产物的创新开发和改性--如海藻酸盐(ALG)、壳聚糖、透明质酸(HA)、明胶、肝素(HEP)等。和合成的-(例如聚酯、聚乙烯亚胺(PEI)等)以聚合物为基础的聚合物导致了设计药物输送水凝胶系统的各种方法，从水凝胶系统中释放负载的治疗剂。本文综述了通过聚合物和多肽的自组装、化学交联、离子交联和生物分子识别而形成的各种水凝胶的研究现状。生物活性因子缓释水凝胶的设计是第一部分的重点。第二部分详细讨论了用于治疗药物的水凝胶的有效载荷的释放策略，如物理结合、共价连接、亲和作用、按需释放和/或杂化聚合物支架的使用，重点是最近5年。
Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural-(e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic-(e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years.
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影响因子：
14
作者：
Bian, Liming;Zhai, David Y.;Tous, Elena;Rai, Reena;Mauck, Robert L.;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
14
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影响因子：
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影响因子：
14
作者：
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通讯作者：
Sinko, Patrick J.