Opioid treatment program and community pharmacy collaboration for methadone maintenance treatment: results from a feasibility clinical trial.
Opioid treatment program and community pharmacy collaboration for methadone maintenance treatment: results from a feasibility clinical trial.
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DOI：
10.1111/add.15641
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Schwartz RP
中科院分区：
文献类型：
--
作者：
Wu LT;John WS;Morse ED;Adkins S;Pippin J;Brooner RK;Schwartz RP
美沙酮维持治疗（MMT）的药学管理和配药可以扩大阿片类药物使用障碍（OUD）的治疗可及性。本研究调查了一种新模式的可行性和可接受性，该模式允许阿片类药物治疗项目（OTP）医生通过与合作药房合作，为OUD治疗开美沙酮。非随机、单臂、开放标签可行性试验。在美国有一个OTP和一个社区药房。一名OTP医生，两名药剂师和20名MMT患者接受6至13次5-160毫克/天的美沙酮带回家剂量。患者的美沙酮给药和配发带回家剂量从OTP转移到药房，为期3个月。主要结局是药物依从性。次要结果包括招募、治疗保持、药物使用、OTP咨询出席率、药剂师处方药物监测计划（PDMP）使用、安全性和满意度。在29名符合预筛查条件的患者中，20名患者（69%）参加了研究。招聘时间为2020年8月6日至2020年10月7日。第3个月的治疗保留率为80%（16/20）。两名参与者因为工作/时间表的改变而提前返回OTP，一名是因为怀孕，还有一名是因为与研究无关的住院治疗。保留的16例患者的药物依从性为100%。干预保真度为100%。所有参与者都参加了随机回访。没有证据显示美沙酮被篡改或转移。药剂师在所有就诊时都检查了PDMP。所有参与者都按计划参加了心理咨询。无非法阿片类药物使用尿液筛查阳性，无研究相关不良事件。所有参与者都赞同“药房是MMT接受美沙酮的合适地点”，88%的人赞同“在药房接受美沙酮方便或非常方便”，88%的人对所提供的治疗质量感到满意或非常满意。这项可行性试验发现，在美沙酮维持治疗中，医生处方美沙酮的药房管理和配药是可行和可接受的。
Pharmacy administration and dispensing of methadone for methadone maintenance treatment (MMT) can expand treatment access for opioid use disorder (OUD). This study investigated the feasibility and acceptability of a novel model permitting an opioid treatment program (OTP) physician to prescribe methadone for OUD treatment through collaboration with a partnered pharmacy. Nonrandomized, single-arm, open-label feasibility trial. One OTP and one community pharmacy in the US. One OTP physician, two pharmacists, and 20 MMT patients receiving between 6 and 13 take-home methadone doses at 5–160 mg/day. Patients’ methadone administration and dispensing of take-home doses was transferred from the OTP to the pharmacy for 3 months. Primary outcome was medication adherence. Secondary outcomes were recruitment, treatment retention, substance use, counseling attendance at the OTP, pharmacist prescription drug monitoring program (PDMP) use, safety, and satisfaction. Of 29 patients eligible at prescreen, 20 patients (69%) enrolled into the study. Recruitment occurred from August 6, 2020 to October 7, 2020. Treatment retention rate at Month 3 was 80% (16/20). Two participants returned early to the OTP because of a work/schedule change, one due to pregnancy, and one following a non-study related hospitalization. Medication adherence among 16 patients who were retained was 100%. Intervention fidelity was 100%. All participants attended random call-back visits. None showed evidence of tampering/diversion of methadone. Pharmacists checked the PDMP at all visits. All participants attended psychosocial counseling as planned. There were no positive urine screens for illicit opioid use and no study-related adverse events. All participants endorsed “pharmacy is the right location for receiving methadone for MMT,” 88% endorsed “convenient or very convenient to receive methadone at the pharmacy, and 88% were satisfied or very satisfied with the quality of treatment offered. This feasibility trial has found pharmacy administration and dispensing of physician-prescribed methadone for methadone maintenance treatment to be feasible and acceptable.
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影响因子：
4.2
作者：
Joudrey PJ;Chadi N;Roy P;Morford KL;Bach P;Kimmel S;Wang EA;Calcaterra SL
通讯作者：
Calcaterra SL
DOI：
10.1016/j.sapharm.2018.06.006
发表时间：
2019-04-01
影响因子：
3.9
作者：
Look, Kevin A.;Kile, Mercedes;Roberts, Andrew
通讯作者：
Roberts, Andrew
影响因子：
5.5
作者：
Eibl JK;Gomes T;Martins D;Camacho X;Juurlink DN;Mamdani MM;Dhalla IA;Marsh DC
通讯作者：
Marsh DC
影响因子：
2.3
作者：
Borrelli B
通讯作者：
Borrelli B
影响因子：
3.9
作者：
Amiri, Solmaz;Lutz, Robert;Amram, Ofer
通讯作者：
Amram, Ofer