Timing the day: what makes bacterial clocks tick?

Timing the day: what makes bacterial clocks tick?
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DOI:
10.1038/nrmicro.2016.196
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发表时间:
2017-04
期刊:
Nature reviews. Microbiology
影响因子:
--
通讯作者:
Mori T
Mori T
中科院分区:
其他
文献类型:
--
作者:
Johnson CH;Zhao C;Xu Y;Mori T

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原核生物的时间生物学研究通常远远落后于真核生物内源性生物钟的研究,而真核生物的内源性生物钟系统基本上是普遍存在的。然而,尽管只在过去的25年中进行了研究,蓝藻已成为重要的模式生物的昼夜节律的研究,目前,他们的计时机制是最好的理解任何系统的生物化学结构生物学,生物物理学和适应的重要性。然而,内在的每日节律之间的细菌以外的蓝藻基本上是未知的,一些诱人的信息表明,广泛的日常计时真细菌和古细菌通过机制,共享共同的元素与蓝藻时钟,但不同的。此外,最近关于微生物组-宿主相互作用的信息激增,在很大程度上忽略了时间维度,但日常周期控制着它们之间关系的重要方面。
Chronobiological studies of prokaryotic organisms have generally lagged far behind the study of endogenous circadian clocks in eukaryotes, in which such systems are essentially ubiquitous. However, despite only being studied during the past 25 years, cyanobacteria have become important model organisms for the study of circadian rhythms and, presently, their timekeeping mechanism is the best understood of any system in terms of biochemistry structural biology, biophysics and adaptive importance. Nevertheless, intrinsic daily rhythmicity among bacteria other than cyanobacteria is essentially unknown; some tantalizing information suggests widespread daily timekeeping among Eubacteria and Archaea through mechanisms that share common elements with the cyanobacterial clock but are distinct. Moreover, the recent surge of information about microbiome–host interactions has largely neglected the temporal dimension and yet daily cycles control important aspects of their relationship.
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