Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer.
Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer.
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DOI：
10.3892/ol.2017.6963
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发表时间：
2017-11
期刊：
影响因子：
2.9
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zhang S;Lei R;Wu J;Shan J;Hu Z;Chen L;Ren X;Yao L;Wang J;Wang X
高迁移率族A1（HMGA 1）蛋白与多种癌症患者的预后不良相关。然而，HMGA 1对乳腺癌（BC）死亡风险的影响尚未得到充分表征。在本回顾性多中心研究中，通过对来自浙江大学第二附属医院（中国浙江）的273个BC标本和来自生物芯片国家工程中心（中国上海）的310个BC的手术组织样本进行免疫组织化学测定HMGA 1表达水平。生存率分析采用Kaplan-Meier分析和考克斯比例风险模型。HMGA 1表达与肿瘤组织学分级和体重指数（BMI）显著相关。然而，HMGA 1表达在BC患者中没有预后价值。HMGA 1表达和高BMI（≥24 kg/m2）联合评估可预测BC的总体生存率较差。因此，HMGA 1和BMI在BC的发生、发展中具有协同作用，联合检测HMGA 1表达和高BMI可能是预测BC患者预后不良的有效指标。
The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was determined by performing immunohistochemistry on surgical tissue samples of 273 BC specimens from the Second Affiliated Hospital of Zhejiang University (Zhejiang, China) and 310 BCs from the National Engineering Center for Biochip (Shanghai, China). Kaplan-Meier analysis and Cox proportional hazard model were employed to analyze the survivability. HMGA1 expression was significantly associated with tumor histological degree and body mass index (BMI). However, HMGA1 expression showed no prognostic value in patients with BC. Combined evaluation of HMGA1 expression and high BMI (≥24 kg/m2) predicted worse overall survival of BC. Therefore, HMGA1 and BMI were considered to serve synergistic roles in the development and progression of BC, and combined evaluation of HMGA1 expression and high BMI may be an effective marker in predicting poor prognosis of BC patients.
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DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
--
作者：
Pegoraro S;Ros G;Ciani Y;Sgarra R;Piazza S;Manfioletti G
通讯作者：
Manfioletti G
影响因子：
4.8
作者：
Ganz ML;Wintfeld N;Li Q;Alas V;Langer J;Hammer M
通讯作者：
Hammer M
影响因子：
11.5
作者：
Chiappetta, G;Botti, G;Fusco, A
通讯作者：
Fusco, A
影响因子：
4.6
作者：
Chiefari, Eusebio;Tanyolac, Sinan;Brunetti, Antonio
通讯作者：
Brunetti, Antonio