The kinetochore.

The kinetochore.
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动力学。

DOI:
10.1101/cshperspect.a015826
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发表时间:
2014-07-01
影响因子:
7.2
通讯作者:
Cheeseman IM
Cheeseman IM
中科院分区:
生物学1区
文献类型:
--
作者:
Cheeseman IM

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有丝分裂的一个关键条件是遗传物质分布到两个子细胞。在这一过程中起核心作用的是大分子着丝点结构,它与染色体DNA和纺锤体微管聚合物结合,指导染色体排列和分离。本章将讨论有丝分裂染色体分离所需的关键着丝点活动,包括识别每条染色体上的特定位点,着丝点组装和着丝点-微管连接的形成,驱动染色体分离的力的产生,以及调节着丝点功能以确保染色体分离的高保真度。
A critical requirement for mitosis is the distribution of the genetic material to the two daughter cells. The central player in this process is the macromolecular kinetochore structure, which binds to both chromosomal DNA and spindle microtubule polymers to direct chromosome alignment and segregation. This chapter will discuss the key kinetochore activities required for mitotic chromosome segregation including the recognition of a specific site on each chromosome, kinetochore assembly and the formation of kinetochore-microtubule connections, the generation of force to drive chromosome segregation, and the regulation of kinetochore function to ensure that chromosome segregation occurs with high fidelity.
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