The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly.
The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly.
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基因组自交综合症伴随着异质性的进化崩溃
DOI：
10.1093/molbev/msaa199
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发表时间：
2021-01-04
影响因子：
10.7
通讯作者：
Zhou W
中科院分区：
文献类型：
--
作者：
Wang XJ;Barrett SCH;Zhong L;Wu ZK;Li DZ;Wang H;Zhou W
摘要：从异型杂交到自交的进化转变可能会产生重要的基因组后果。预计有效种群规模的减少和选择效率的降低将在自交物种基因组的分子进化中发挥重要作用。我们使用 66 种报春花（包括双柱（异交）和衍生的同柱（自交）类群）研究了基因组自交综合症的分子特征证据。我们通过对中原草的微进化研究补充了我们的比较分析，中原草具有交配系统的多态性，并且由双花柱和同花柱群体组成。我们生成了双柱、同柱和双柱-同柱物种的叶绿体和核基因组数据集，并确定了具有对比交配系统的物种或谱系中非同义到同义分歧（dN/dS）和多态性（πN/πS）的模式。我们对编码序列分歧和多态性的分析发现，与双花群体相比，同花群体样本中的遗传多样性和杂合性大大降低，纯化选择的效率降低，大效应有害突变的清除以及适应性进化率降低，这与基因组自交综合症的理论预期一致。我们的结果表明，自体受精是分子进化过程的主要驱动力，自交基因组特征在年老和相对年轻的同型群体中都很明显。
Abstract The evolutionary transition from outcrossing to selfing can have important genomic consequences. Decreased effective population size and the reduced efficacy of selection are predicted to play an important role in the molecular evolution of the genomes of selfing species. We investigated evidence for molecular signatures of the genomic selfing syndrome using 66 species of Primula including distylous (outcrossing) and derived homostylous (selfing) taxa. We complemented our comparative analysis with a microevolutionary study of P. chungensis, which is polymorphic for mating system and consists of both distylous and homostylous populations. We generated chloroplast and nuclear genomic data sets for distylous, homostylous, and distylous–homostylous species and identified patterns of nonsynonymous to synonymous divergence (dN/dS) and polymorphism (πN/πS) in species or lineages with contrasting mating systems. Our analysis of coding sequence divergence and polymorphism detected strongly reduced genetic diversity and heterozygosity, decreased efficacy of purifying selection, purging of large-effect deleterious mutations, and lower rates of adaptive evolution in samples from homostylous compared with distylous populations, consistent with theoretical expectations of the genomic selfing syndrome. Our results demonstrate that self-fertilization is a major driver of molecular evolutionary processes with genomic signatures of selfing evident in both old and relatively young homostylous populations.
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影响因子：
3.3
作者：
Bachtrog, Doris;Andolfatto, Peter
通讯作者：
Andolfatto, Peter
影响因子：
3.3
作者：
Cutter, Asher D.;Wasmuth, James D.;Washington, Nicole L.
通讯作者：
Washington, Nicole L.
影响因子：
2.9
作者：
CHARLESWORTH, B;CHARLESWORTH, D
通讯作者：
CHARLESWORTH, D
DOI：
10.1098/rstb.1996.0110
发表时间：
1996-09-30
影响因子：
6.3
作者：
Barrett, SCH;Harder, LD;Worley, AC
通讯作者：
Worley, AC
DOI：
10.1111/nph.13370
发表时间：
2015-10
期刊：
The New phytologist
影响因子：
--
作者：
Cocker JM;Webster MA;Li J;Wright J;Kaithakottil G;Swarbreck D;Gilmartin PM
通讯作者：
Gilmartin PM