Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function.
Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function.
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DOI：
10.1002/eji.200838295
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发表时间：
2008-11
影响因子：
5.4
通讯作者：
Miceli, M. Carrie
中科院分区：
文献类型：
--
作者：
Motran, Claudia C.;Molinder, Karen M.;Liu, Scot D.;Poirier, Francoise;Miceli, M. Carrie
Galectin-1 has been implicated in regulating T cell survival, function, and Th1/Th2 balance in several mouse models, though the molecular and cellular basis of its immuno-modulatory activity has not been completely elucidated. Therefore, we examined galectin-1 expression and activity within differentiated murine Th1 and Th2 subsets. While recombinant galectin-1 specifically bound to both T cell subsets, Th1 and Th2 T cells expressed distinct combinations of galectin-1 reactive epitopes and were differentially responsive to galectin-1 exposure. Indeed, Th1 cells were more susceptible to galectin-1 induced death than Th2 cells. Th2 protection from apoptosis was correlated with expression of anti-apoptotic galectin-3. Further, galectin-1 promoted TCR-induced type 2 cytokine production by Th2 cells. Differentiated Th2 cells constitutively expressed high levels of galectin-1 and can be induced to produce even higher levels of galectin-1 with restimulation, whereas comparable levels of galectin-1 in Th1 cells were only observed after re-stimulation. Co-culturing experiments using galectin-1−/− and galectin-1+/+ Th1 and Th2 T cells demonstrated that Th2-derived galectin-1 induced Th1 apoptosis, whereas Th1-derived galectin-1 promoted Th2 cytokine production. These studies identify galectin-1 as a cross-regulatory cytokine that selectively antagonizes Th1 survival, while promoting TCR-induced Th2 cytokine production.
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DOI：
10.1084/jem.182.5.1591
发表时间：
1995-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Constant S;Pfeiffer C;Woodard A;Pasqualini T;Bottomly K
通讯作者：
Bottomly K
影响因子：
4.4
作者：
Chung, CD;Patel, VP;Miceli, MC
通讯作者：
Miceli, MC
影响因子：
4.4
作者：
Morgan, R;Gao, GY;Li, BY
通讯作者：
Li, BY
影响因子：
32.4
作者：
Balamuth, F;Leitenberg, D;Bottomly, K
通讯作者：
Bottomly, K
DOI：
10.1084/jem.185.10.1851
发表时间：
1997-05-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Perillo NL;Uittenbogaart CH;Nguyen JT;Baum LG
通讯作者：
Baum LG