Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling.
Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling.
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先天免疫细胞在压力过载引起的心脏肥大和重塑中的作用
DOI：
10.3389/fcell.2021.659666
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发表时间：
2021
影响因子：
5.5
通讯作者：
Guo J
中科院分区：
文献类型：
--
作者：
Liu X;Shi GP;Guo J
压力超载和心力衰竭是心血管疾病发病和死亡的主要原因。越来越多的证据表明，炎症细胞的激活和炎症介质的释放在这些心脏病的发病过程中起着至关重要的作用。然而，先天免疫细胞和随后的炎症事件在这些过程中的作用仍然知之甚少。在这里，我们概述了先天免疫细胞参与这些病理过程的可能潜在机制，包括肥大细胞、巨噬细胞、单核细胞、中性粒细胞、树突状细胞、嗜酸性粒细胞和自然杀伤T细胞。虽然这些细胞在压力过载后的不同时间点积聚在心房或心室，但它们对心脏的保护或破坏作用各不相同。其中肥大细胞、中性粒细胞和树突状细胞在实验模型中发挥有害作用，而嗜酸性粒细胞和自然杀伤T细胞则表现出保护心脏的活性。根据它们的亚群，巨噬细胞和单核细胞可能加剧心脏功能异常或负性调节心脏肥厚和重塑。压力过载刺激先天免疫细胞，甚至是常驻的心肌细胞分泌细胞因子、趋化因子和生长因子，共同帮助先天免疫细胞浸润到受损的心脏。这些浸润与促肥厚事件和心脏成纤维细胞活化有关。心脏先天免疫细胞的免疫调控成为实验性心脏病治疗的一种有前景的治疗方法，凸显了其在人体临床评价中的重要意义。
Pressure overload and heart failure are among the leading causes of cardiovascular morbidity and mortality. Accumulating evidence suggests that inflammatory cell activation and release of inflammatory mediators are of vital importance during the pathogenesis of these cardiac diseases. Yet, the roles of innate immune cells and subsequent inflammatory events in these processes remain poorly understood. Here, we outline the possible underlying mechanisms of innate immune cell participation, including mast cells, macrophages, monocytes, neutrophils, dendritic cells, eosinophils, and natural killer T cells in these pathological processes. Although these cells accumulate in the atrium or ventricles at different time points after pressure overload, their cardioprotective or cardiodestructive activities differ from each other. Among them, mast cells, neutrophils, and dendritic cells exert detrimental function in experimental models, whereas eosinophils and natural killer T cells display cardioprotective activities. Depending on their subsets, macrophages and monocytes may exacerbate cardiodysfunction or negatively regulate cardiac hypertrophy and remodeling. Pressure overload stimulates the secretion of cytokines, chemokines, and growth factors from innate immune cells and even resident cardiomyocytes that together assist innate immune cell infiltration into injured heart. These infiltrates are involved in pro-hypertrophic events and cardiac fibroblast activation. Immune regulation of cardiac innate immune cells becomes a promising therapeutic approach in experimental cardiac disease treatment, highlighting the significance of their clinical evaluation in humans.
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影响因子：
3.3
作者：
ATKINSON, JB;ROBINOWITZ, M;VIRMANI, R
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