Regulation of Inflammatory Cytokines for Spinal Cord Injury Repair Through Local Delivery of Therapeutic Agents.
Regulation of Inflammatory Cytokines for Spinal Cord Injury Repair Through Local Delivery of Therapeutic Agents.
复制标题
通过局部递送治疗剂调节炎症细胞因子修复脊髓损伤
DOI：
10.1002/advs.201800529
复制
发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Ren H;Chen X;Tian M;Zhou J;Ouyang H;Zhang Z
脊髓损伤(SCI)是人类最具破坏性的创伤之一，炎症平衡对脊髓损伤的修复至关重要。炎症细胞因子是局部炎症的直接介质，对损伤脊髓的修复有不同的影响。在脊髓损伤模型中，一些炎性细胞因子被证明是有益的，而另一些则是有害的。各种动物研究表明，局部给药能有效地调节炎性细胞因子，促进脊髓损伤的修复。相当多的临床研究也表明，通过调节炎症细胞因子促进脊髓损伤的修复。然而，单一药物的局部给药只影响需要调节的部分炎性细胞因子。同时，不同的个体具有不同的炎性细胞因子谱。因此，未来的研究目标可能是开发个性化的局部给药鸡尾酒治疗策略，以有效和精确地调节炎症，并从脊髓损伤中实质性地恢复功能。
The balance of inflammation is critical to the repair of spinal cord injury (SCI), which is one of the most devastating traumas in human beings. Inflammatory cytokines, the direct mediators of local inflammation, have differential influences on the repair of the injured spinal cord. Some inflammatory cytokines are demonstrated beneficial to spinal cord repair in SCI models, while some detrimental. Various animal researches have revealed that local delivery of therapeutic agents efficiently regulates inflammatory cytokines and promotes repair from SCI. Quite a few clinical studies have also shown the promotion of repair from SCI through regulation of inflammatory cytokines. However, local delivery of a single agent affects only a part of the inflammatory cytokines that need to be regulated. Meanwhile, different individuals have differential profiles of inflammatory cytokines. Therefore, future studies may aim to develop personalized strategies of locally delivered therapeutic agent cocktails for effective and precise regulation of inflammation, and substantial functional recovery from SCI.
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DOI：
10.1073/pnas.0812690106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Cayrol, Corinne;Girard, Jean-Philippe
通讯作者：
Girard, Jean-Philippe
DOI：
10.1080/10790268.2016.1177348
发表时间：
2016-05-01
期刊：
The journal of spinal cord medicine
影响因子：
--
作者：
通讯作者：
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影响因子：
15.3
作者：
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通讯作者：
Sinigaglia, F
影响因子：
3.8
作者：
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通讯作者：
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影响因子：
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作者：
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