Identification of a functional transposon insertion in the maize domestication gene tb1.
Identification of a functional transposon insertion in the maize domestication gene tb1.
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作者：
由转座元件产生的遗传多样性是进化过程中选择作用的功能变异的重要来源。转座元件与果蝇对温带气候的适应有关，正弦元件与灰狼的小型犬种的驯化有关，并且有证据表明转座元件是人类进化过程中选择的目标。尽管与宿主基因功能相关的转座元件的例子不断增加，但转座元件是致病因素而不仅仅是与功能变异相关的证据仍然有限。在这里，我们表明，插入玉米驯化基因大蜀黍分支1（tb1）调控区的转座元件（Hopscotch）充当基因表达的增强子，并部分解释了与其祖先大蜀黍相比，玉米顶端优势增加的原因。分子测年表明，跳房子的插入比玉米驯化早至少一万年，这表明选择作用于长期变异而不是新突变。
Genetic diversity created by transposable elements is an important source of functional variation upon which selection acts during evolution. Transposable elements are associated with adaptation to temperate climates in Drosophila, a SINE element is associated with the domestication of small dog breeds from the gray wolf and there is evidence that transposable elements were targets of selection during human evolution. Although the list of examples of transposable elements associated with host gene function continues to grow, proof that transposable elements are causative and not just correlated with functional variation is limited. Here we show that a transposable element (Hopscotch) inserted in a regulatory region of the maize domestication gene, teosinte branched1 (tb1), acts as an enhancer of gene expression and partially explains the increased apical dominance in maize compared to its progenitor, teosinte. Molecular dating indicates that the Hopscotch insertion predates maize domestication by at least 10,000 years, indicating that selection acted on standing variation rather than new mutation.
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影响因子：
64.8
作者：
Doebley, J;Stec, A;Hubbard, L
通讯作者：
Hubbard, L
DOI：
10.1073/pnas.97.13.7360
发表时间：
2000-06-20
影响因子：
11.1
作者：
Thomson, R;Pritchard, JK;Feldman, MW
通讯作者：
Feldman, MW
影响因子：
3.9
作者：
Hudson, Richard R.
通讯作者：
Hudson, Richard R.
影响因子：
56.9
作者：
BENFEY, PN;CHUA, NH
通讯作者：
CHUA, NH
影响因子：
3.3
作者：
Fukunaga, K;Hill, J;Doebley, J
通讯作者：
Doebley, J