Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?
Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?
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DOI：
10.1016/j.smim.2022.101628
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发表时间：
2022-01
影响因子：
7.8
通讯作者：
Lomoio, Selene
中科院分区：
文献类型：
--
作者：
Tesco, Giuseppina;Lomoio, Selene
神经退行性疾病（ND）是异质性神经系统疾病，其特征在于所选择的神经元群体的进行性丧失。大多数ND的一个重要风险因素是衰老。考虑到预期寿命的不断增加，ND代表了全球公共卫生负担。轴突运输（AT）是神经元结构和连接的产生和维持的核心细胞过程，并且似乎是大多数（如果不是全部）ND的共同线索。众所周知，神经炎症很难定义与ND的关系。炎症是CNS中的复杂多因素过程，其根据疾病阶段而变化。有证据表明AT缺陷、轴突病变和神经炎症密切相关。然而，这些损伤是否在ND中起着致病作用，或者仅仅是神经元变性的下游效应，仍然没有定论。我们仍然缺乏可靠的信息，这些致病机制之间的时间关系，虽然一些研究结果表明，它们可能发生在ND的病理生理早期。本文将回顾AT扰动和CNS炎症的某些方面之间的相互作用是否可以参与ND病因学的最新证据，分析其作为治疗靶点的潜力，以及确定早期替代生物标志物的迫切性。创建于BioRender.com
Neurodegenerative diseases (NDs) are heterogeneous neurological disorders characterized by a progressive loss of selected neuronal populations. A significant risk factor for most NDs is aging. Considering the constant increase in life expectancy, NDs represent a global public health burden. Axonal transport (AT) is a central cellular process underlying the generation and maintenance of neuronal architecture and connectivity and appears to be a common thread for most, if not all, NDs. Neuroinflammation has been notoriously difficult to define in relation to NDs. Inflammation is a complex multifactorial process in the CNS, which varies depending on the disease stage. Several lines of evidence suggest that AT defect, axonopathy and neuroinflammation are tightly interlaced. However, whether these impairments play a causative role in NDs or are merely a downstream effect of neuronal degeneration remains unsettled. We still lack reliable information on the temporal relationship between these pathogenic mechanisms, although several findings suggest that they may occur early during ND pathophysiology. This article will review the latest evidence emerging on whether the interplay between AT perturbations and some aspects of CNS inflammation can participate in ND etiology, analyze their potential as therapeutic targets, and the urge to identify early surrogate biomarkers. Created with BioRender.com
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影响因子：
6.1
作者：
Brady ST;Morfini GA
通讯作者：
Morfini GA
DOI：
10.1038/s41531-017-0008-2
发表时间：
2017
期刊：
NPJ Parkinson's disease
影响因子：
--
作者：
Bereczki E;Bogstedt A;Höglund K;Tsitsi P;Brodin L;Ballard C;Svenningsson P;Aarsland D
通讯作者：
Aarsland D
影响因子：
9.9
作者：
Alcolea, Daniel;Vilaplana, Eduard;Lleo, Alberto
通讯作者：
Lleo, Alberto
DOI：
10.1523/jneurosci.4065-10.2011
发表时间：
2011-01-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barrientos SA;Martinez NW;Yoo S;Jara JS;Zamorano S;Hetz C;Twiss JL;Alvarez J;Court FA
通讯作者：
Court FA
影响因子：
5.1
作者：
Brady, Scott;Morfini, Gerardo
通讯作者：
Morfini, Gerardo