The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children.
The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children.
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DOI：
10.1111/nmo.14035
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发表时间：
2021-05
影响因子：
3.5
通讯作者：
Bradshaw LA
中科院分区：
文献类型：
--
作者：
Somarajan S;Muszynski ND;Olson JD;Comstock A;Russell AC;Walker LS;Acra SA;Bradshaw LA
青少年功能性胃肠道疾病的慢性恶心是一种越来越多的报道，但了解甚少的症状，对生活质量产生负面影响。已知功能性胃肠道疾病与慢波节律紊乱密切相关。功能性恶心患者胃电生理紊乱的特征化能力可以为恶心患者提供潜在的诊断和治疗工具。我们使用高分辨率胃电图（HR-EGG）测量儿童慢性恶心患者和健康受试者餐前和餐后的胃慢波参数。我们计算了主频率，百分比功率分布，胃慢波传播方向，和速度从HR-EGG。我们观察到显着差异的主频和功率分布在正常和缓慢心律失常的频率范围内比较患者和健康受试者。健康受试者的传播模式主要是顺行，而患者表现出各种异常，包括逆行，顺行和中断模式。健康受试者（222° ± 22°）和患者（103° ± 66°; p <0.01）之间的餐前平均慢波方向存在显著差异，但健康受试者和患者之间的餐后平均方向相似（p = 0.73）。在餐前（p = 0.21）或餐后（p = 0.75），患者和健康受试者之间的慢波传播速度无显著差异。使用HR-EGG的胃慢波活动的时空特征区分有症状的慢性恶心患者和健康受试者。这种表征可以反过来通知和指导临床决策，并导致进一步深入了解其病理生理学。
Chronic nausea in adolescents with functional gastrointestinal disorders is an increasingly reported but poorly understood symptom that negatively affects quality of life. Functional gastrointestinal disorders are known to correlate closely with slow wave rhythm disturbances. The ability to characterize gastric electrophysiologic perturbations in functional nausea patients could provide potential diagnostic and therapeutic tools for nausea patients. We used high-resolution electrogastrograms (HR-EGG) to measure gastric slow wave parameters in pediatric chronic nausea patients and healthy subjects both pre- and postprandial. We computed the dominant frequency, percentage power distribution, gastric slow wave propagation direction, and speed from HR-EGG. We observed significant differences in the dominant frequency and power distributed in normal and bradyarrhythmia frequency ranges when comparing patients and healthy subjects. Propagation patterns in healthy subjects were predominantly anterograde, while patients exhibited a variety of abnormalities including retrograde, anterograde, and disrupted patterns. There was a significant difference in the preprandial mean slow wave direction between healthy subjects (222° ± 22°) and patients (103° ± 66°; p ˂ 0.01), although the postprandial mean direction between healthy subjects and patients was similar (p = 0.73). No significant difference in slow wave propagation speed was found between patients and healthy subjects in either pre- (p = 0.21) or postprandial periods (p = 0.75). The spatiotemporal characterization of gastric slow wave activity using HR-EGG distinguishes symptomatic chronic nausea patients from healthy subjects. This characterization may in turn inform and direct clinical decision-making and lead to further insight into its pathophysiology.
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影响因子：
3.1
作者：
Riezzo, G;Chiloiro, M;Cucchiara, S
通讯作者：
Cucchiara, S
影响因子：
5.4
作者：
Belouchrani, A;AbedMeraim, K;Moulines, E
通讯作者：
Moulines, E
影响因子：
1.9
作者：
Pfaffenbach, B;Wegener, M;Ricken, D
通讯作者：
Ricken, D
影响因子：
3.2
作者：
Bradshaw, LA;Richards, WO;Wikswo, JP
通讯作者：
Wikswo, JP
影响因子：
3.5
作者：
Bradshaw LA;Cheng LK;Chung E;Obioha CB;Erickson JC;Gorman BL;Somarajan S;Richards WO
通讯作者：
Richards WO