Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity.-猫眼课题宝

DOI：

10.2741/3657

发表时间：

2010-06-01

期刊：

Frontiers in bioscience (Landmark edition)

影响因子：

通讯作者：

中科院分区：

其他

文献类型：

作者：

Mai J;Wang H;Yang XF

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880832/?report=classic

分泌白细胞介素-17（IL-17）的辅助性T细胞17（Th 17）是最近鉴定的CD 4+辅助性T细胞亚群，其与多种炎症和自身免疫性疾病有关。Th 17、沿着CD 4 + CD 25 high Foxp 3+调节性T细胞（TfT）和其他新出现的T辅助细胞亚群Th 9和Tfh扩展了Th 1-Th 2范例。虽然这一新提出的六亚群模式显著提高了我们对CD 4+辅助性T细胞亚群的分化以及T辅助性细胞在炎症和自身免疫中的调节的理解，但仍有许多问题有待回答。本文就以下几个问题进行简要综述：（a）旧的Th 1-Th 2模式与新的多亚群模式;（B）IL-17家族细胞因子的结构特征;（c）Th 17细胞;（d）IL-17对不同细胞类型和组织的作用;（e）IL-17受体和信号通路;（f）Th 17介导的炎症;（g）IL-17在感染中的保护机制。最后，我们将研究Th 17和Treg在自身免疫性疾病和炎症中的相互作用：Th 17细胞与Treg相互作用。自身免疫和炎症的调节在于不同T辅助细胞亚群的相互作用，因此，更好地了解这些亚群彼此之间的相互作用将大大改善我们开发治疗炎症和自身免疫性疾病的方法。

Interleukin-17 (IL-17)-secreting T helper 17 cells (Th17) are a recently identified CD4+ T helper subset that has been implicated in various inflammatory and autoimmune diseases. Th17, along with CD4+CD25high Foxp3+ regulatory T cells (Tregs) and other newly emergent T helper subsets, Th9 and Tfh, have expanded the Th1-Th2 paradigm. Although this newly proposed six-subset paradigm significantly improved our understanding on the differentiation of CD4+ T helper cell subsets and the regulation of T helper cells in inflammation and autoimmunity, many questions remain to be answered. In this overview, we will briefly review the following issues: a) Old Th1-Th2 paradigm versus new multi-subset paradigm; b) Structural features of IL-17 family cytokines; c) Th17 cells; d) Effects of IL-17 on various cell types and tissues; e) IL-17 receptor and signaling pathways; f) Th17-mediated inflammations; and g) Protective mechanisms of IL-17 in infections. Lastly, we will look into the interaction of Th17 and Treg in autoimmune diseases and inflammation: Th17 cells interplay with Tregs. Regulation of autoimmunity and inflammation lies in the interplays of the different T helper subsets, therefore, better understanding of these subsets’ interactions with one another would greatly improve our approaches in developing therapy to combat inflammatory and autoimmune diseases.

Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity.

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