Promising New Agents for Colorectal Cancer.
Promising New Agents for Colorectal Cancer.
复制标题
有希望的结直肠癌的新药物。
DOI:
10.1007/s11864-018-0543-z
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发表时间:
2018-05-11
影响因子:
4.3
通讯作者:
Goldberg RM
中科院分区:
文献类型:
--
作者:
Das S;Ciombor KK;Haraldsdottir S;Goldberg RM
There are many exciting new therapies being developed for mCRC patients. Beyond adding to existing combination backbones of chemotherapy with oxaliplatin and irinotecan, subsets of mCRC patients have been identified who may benefit from novel treatments such as immune checkpoint blockade, HER2 inhibition, and MAPK blockade through targeting RAS and RAF based on genomic profiling from NGS. Other patients have demonstrated responses with developmental therapeutics including cytotoxic-conjugated antibodies targeting CEA, bi-specific antibodies drawing CD3 expressing T cells to tumor cells, metabolic modifiers to increase T cell proliferation at the tumor interface and epigenetic modulators preventing export of key tumor suppressor proteins. How to sequence these new options and determine where they fit into the framework of existing treatments remain major questions whose answers we hope to determine through ongoing clinical trials.
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影响因子:
45.3
作者:
Kopetz, Scott;Chang, George J.;McWilliams, Robert R.
通讯作者:
McWilliams, Robert R.
DOI:
10.1056/nejmoa1714448
发表时间:
2018-02-22
期刊:
The New England journal of medicine
影响因子:
--
作者:
Drilon A;Laetsch TW;Kummar S;DuBois SG;Lassen UN;Demetri GD;Nathenson M;Doebele RC;Farago AF;Pappo AS;Turpin B;Dowlati A;Brose MS;Mascarenhas L;Federman N;Berlin J;El-Deiry WS;Baik C;Deeken J;Boni V;Nagasubramanian R;Taylor M;Rudzinski ER;Meric-Bernstam F;Sohal DPS;Ma PC;Raez LE;Hechtman JF;Benayed R;Ladanyi M;Tuch BB;Ebata K;Cruickshank S;Ku NC;Cox MC;Hawkins DS;Hong DS;Hyman DM
通讯作者:
Hyman DM
影响因子:
7.2
作者:
Bacac M;Klein C;Umana P
通讯作者:
Umana P
影响因子:
50.3
作者:
Corcoran RB;Cheng KA;Hata AN;Faber AC;Ebi H;Coffee EM;Greninger P;Brown RD;Godfrey JT;Cohoon TJ;Song Y;Lifshits E;Hung KE;Shioda T;Dias-Santagata D;Singh A;Settleman J;Benes CH;Mino-Kenudson M;Wong KK;Engelman JA
通讯作者:
Engelman JA
影响因子:
64.8
作者:
Muzny, Donna M.;Bainbridge, Matthew N.;Chang, Kyle;Dinh, Huyen H.;Drummond, Jennifer A.;Fowler, Gerald;Kovar, Christie L.;Lewis, Lora R.;Morgan, Margaret B.;Newsham, Irene F.;Reid, Jeffrey G.;Santibanez, Jireh;Shinbrot, Eve;Trevino, Lisa R.;Wu, Yuan-Qing;Wang, Min;Gunaratne, Preethi;Donehower, Lawrence A.;Creighton, Chad J.;Wheeler, David A.;Gibbs, Richard A.;Lawrence, Michael S.;Voet, Douglas;Jing, Rui;Cibulskis, Kristian;Sivachenko, Andrey;Stojanov, Petar;McKenna, Aaron;Lander, Eric S.;Gabriel, Stacey;Getz, Gad;Ding, Li;Fulton, Robert S.;Koboldt, Daniel C.;Wylie, Todd;Walker, Jason;Dooling, David J.;Fulton, Lucinda;Delehaunty, Kim D.;Fronick, Catrina C.;Demeter, Ryan;Mardis, Elaine R.;Wilson, Richard K.;Chu, Andy;Chun, Hye-Jung E.;Mungall, Andrew J.;Pleasance, Erin;Robertson, A. Gordon;Stoll, Dominik;Balasundaram, Miruna;Birol, Inanc;Butterfield, Yaron S. N.;Chuah, Eric;Coope, Robin J. N.;Dhalla, Noreen;Guin, Ranabir;Hirst, Carrie;Hirst, Martin;Holt, Robert A.;Lee, Darlene;Li, Haiyan I.;Mayo, Michael;Moore, Richard A.;Schein, Jacqueline E.;Slobodan, Jared R.;Tam, Angela;Thiessen, Nina;Varhol, Richard;Zeng, Thomas;Zhao, Yongjun;Jones, Steven J. M.;Marra, Marco A.;Bass, Adam J.;Ramos, Alex H.;Saksena, Gordon;Cherniack, Andrew D.;Schumacher, Stephen E.;Tabak, Barbara;Carter, Scott L.;Pho, Nam H.;Nguyen, Huy;Onofrio, Robert C.;Crenshaw, Andrew;Ardlie, Kristin;Beroukhim, Rameen;Winckler, Wendy;Getz, Gad;Meyerson, Matthew;Protopopov, Alexei;Zhang, Juinhua;Hadjipanayis, Angela;Lee, Eunjung;Xi, Ruibin;Yang, Lixing;Ren, Xiaojia;Zhang, Hailei;Sathiamoorthy, Narayanan;Shukla, Sachet;Chen, Peng-Chieh;Haseley, Psalm;Xiao, Yonghong;Lee, Semin;Seidman, Jonathan;Chin, Lynda;Park, Peter J.;Kucherlapati, Raju;Auman, J. Todd;Hoadley, Katherine A.;Du, Ying;Wilkerson, Matthew D.;Shi, Yan;Liquori, Christina;Meng, Shaowu;Li, Ling;Turman, Yidi J.;Topal, Michael D.;Tan, Donghui;Waring, Scot;Buda, Elizabeth;Walsh, Jesse;Jones, Corbin D.;Mieczkowski, Piotr A.;Singh, Darshan;Wu, Junyuan;Gulabani, Anisha;Dolina, Peter;Bodenheimer, Tom;Hoyle, Alan P.;Simons, Janae V.;Soloway, Matthew;Mose, Lisle E.;Jefferys, Stuart R.;Balu, Saianand;O'Connor, Brian D.;Prins, Jan F.;Chiang, Derek Y.;Hayes, D. Neil;Perou, Charles M.;Hinoue, Toshinori;Weisenberger, Daniel J.;Maglinte, Dennis T.;Pan, Fei;Berman, Benjamin P.;Van den Berg, David J.;Shen, Hui;Triche, Timothy, Jr.;Baylin, Stephen B.;Laird, Peter W.;Getz, Gad;Noble, Michael;Voet, Doug;Saksena, Gordon;Gehlenborg, Nils;DiCara, Daniel;Zhang, Juinhua;Zhang, Hailei;Wu, Chang-Jiun;Liu, Spring Yingchun;Shukla, Sachet;Lawrence, Michael S.;Zhou, Lihua;Sivachenko, Andrey;Lin, Pei;Stojanov, Petar;Jing, Rui;Park, Richard W.;Nazaire, Marc-Danie;Robinson, Jim;Thorvaldsdottir, Helga;Mesirov, Jill;Park, Peter J.;Chin, Lynda;Thorsson, Vesteinn;Reynolds, Sheila M.;Bernard, Brady;Kreisberg, Richard;Lin, Jake;Iype, Lisa;Bressler, Ryan;Erkkilae, Timo;Gundapuneni, Madhumati;Liu, Yuexin;Norberg, Adam;Robinson, Tom;Da Yang;Zhang, Wei;Shmulevich, Ilya;De Ronde, Jorma J.;Schultz, Nikolaus;Cerami, Ethan;Ciriello, Giovanni;Goldberg, Arthur P.;Gross, Benjamin;Jacobsen, Anders;Gao, Jianjiong;Kaczkowski, Bogumil;Sinha, Rileen;Aksoy, B. Arman;Antipin, Yevgeniy;Reva, Boris;Shen, Ronglai;Taylor, Barry S.;Chan, Timothy A.;Ladanyi, Marc;Sander, Chris;Akbani, Rehan;Zhang, Nianxiang;Broom, Bradley M.;Casasent, Tod;Unruh, Anna;Wakefield, Chris;Hamilton, Stanley R.;Cason, R. Craig;Baggerly, Keith A.;Weinstein, John N.;Haussler, David;Benz, Christopher C.;Stuart, Joshua M.;Benz, Stephen C.;Sanborn, J. Zachary;Vaske, Charles J.;Zhu, Jingchun;Szeto, Christopher;Scott, Gary K.;Yau, Christina;Ng, Sam;Goldstein, Ted;Ellrott, Kyle;Collisson, Eric;Cozen, Aaron E.;Zerbino, Daniel;Wilks, Christopher;Craft, Brian;Spellman, Paul;Penny, Robert;Shelton, Troy;Hatfield, Martha;Morris, Scott;Yena, Peggy;Shelton, Candace;Sherman, Mark;Paulauskis, Joseph;Gastier-Foster, Julie M.;Bowen, Jay;Ramirez, Nilsa C.;Black, Aaron;Pyatt, Robert;Wise, Lisa;White, Peter;Bertagnolli, Monica;Brown, Jen;Chan, Timothy A.;Chu, Gerald C.;Czerwinski, Christine;Denstman, Fred;Dhir, Rajiv;Doerner, Arnulf;Fuchs, Charles S.;Guillem, Jose G.;Iacocca, Mary;Juhl, Hartmut;Kaufman, Andrew;Kohl, Bernard, III;Van Le, Xuan;Mariano, Maria C.;Medina, Elizabeth N.;Meyers, Michael;Nash, Garrett M.;Paty, Phillip B.;Petrelli, Nicholas;Rabeno, Brenda;Richards, William G.;Solit, David;Swanson, Pat;Temple, Larissa;Tepper, Joel E.;Thorp, Richard;Vakiani, Efsevia;Weiser, Martin R.;Willis, Joseph E.;Witkin, Gary;Zeng, Zhaoshi;Zinner, Michael J.;Zornig, Carsten;Jensen, Mark A.;Sfeir, Robert;Kahn, Ari B.;Chu, Anna L.;Kothiyal, Prachi;Wang, Zhining;Snyder, Eric E.;Pontius, Joan;Pihl, Todd D.;Ayala, Brenda;Backus, Mark;Walton, Jessica;Whitmore, Jon;Baboud, Julien;Berton, Dominique L.;Nicholls, Matthew C.;Srinivasan, Deepak;Raman, Rohini;Girshik, Stanley;Kigonya, Peter A.;Alonso, Shelley;Sanbhadti, Rashmi N.;Barletta, Sean P.;Greene, John M.;Pot, David A.;Shaw, Kenna R. Mills;Dillon, Laura A. L.;Buetow, Ken;Davidsen, Tanja;Demchok, John A.;Eley, Greg;Ferguson, Martin;Fielding, Peter;Schaefer, Carl;Sheth, Margi;Yang, Liming;Guyer, Mark S.;Ozenberger, Bradley A.;Palchik, Jacqueline D.;Peterson, Jane;Sofia, Heidi J.;Thomson, Elizabeth
通讯作者:
Thomson, Elizabeth