Promising New Agents for Colorectal Cancer.

Promising New Agents for Colorectal Cancer.
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有希望的结直肠癌的新药物。

DOI:
10.1007/s11864-018-0543-z
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发表时间:
2018-05-11
影响因子:
4.3
通讯作者:
Goldberg RM
Goldberg RM
中科院分区:
医学2区
文献类型:
--
作者:
Das S;Ciombor KK;Haraldsdottir S;Goldberg RM

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有许多令人兴奋的新疗法正在为多发性结直肠癌患者开发。除了增加现有的奥沙利铂和伊立替康联合化疗的骨干外,已经确定了mCRC患者的亚群,他们可能受益于新的治疗方法,如免疫检查点阻断、HER2抑制和MAPK阻断,方法是根据NGS的基因组图谱靶向RAS和RAF。其他患者已经展示了对发育疗法的反应,包括针对CEA的细胞毒结合抗体,将表达CD3的T细胞吸引到肿瘤细胞的双特异性抗体,促进肿瘤界面T细胞增殖的代谢调节剂,以及阻止关键肿瘤抑制蛋白输出的表观遗传调节剂。如何对这些新的选择进行排序并确定它们在现有治疗框架中的位置仍然是主要问题,我们希望通过正在进行的临床试验来确定这些问题的答案。
There are many exciting new therapies being developed for mCRC patients. Beyond adding to existing combination backbones of chemotherapy with oxaliplatin and irinotecan, subsets of mCRC patients have been identified who may benefit from novel treatments such as immune checkpoint blockade, HER2 inhibition, and MAPK blockade through targeting RAS and RAF based on genomic profiling from NGS. Other patients have demonstrated responses with developmental therapeutics including cytotoxic-conjugated antibodies targeting CEA, bi-specific antibodies drawing CD3 expressing T cells to tumor cells, metabolic modifiers to increase T cell proliferation at the tumor interface and epigenetic modulators preventing export of key tumor suppressor proteins. How to sequence these new options and determine where they fit into the framework of existing treatments remain major questions whose answers we hope to determine through ongoing clinical trials.
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发表时间: 2009-08-01
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