Vessel-specific quantification of absolute myocardial blood flow, myocardial flow reserve and relative flow reserve by means of fused dynamic (13)NH(3) PET and CCTA: Ranges in a low-risk population and abnormality criteria.
Vessel-specific quantification of absolute myocardial blood flow, myocardial flow reserve and relative flow reserve by means of fused dynamic (13)NH(3) PET and CCTA: Ranges in a low-risk population and abnormality criteria.
复制标题
通过融合动力学（13）NH（3）PET和CCTA：在低风险人群中的范围和异常标准的范围，对绝对心肌流动，心肌流量储备和相对流量储备的特定定量定量。
DOI：
10.1007/s12350-018-01472-3
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Bom HS
中科院分区：
文献类型：
--
作者：
Piccinelli M;Cho SG;Garcia EV;Alexanderson E;Lee JM;Cooke CD;Goyal N;Sanchez MS;Folks RD;Chen Z;Votaw J;Koo BK;Bom HS
本工作的目的是提出一种新的方法，通过动态PET和CCTA图像的多模态图像融合提取MBF，MFR和RFR沿沿着冠状动脉。血流储备分数是识别血流限制性病变的参考标准，但其侵入性限制了其广泛应用。新的非侵入性方法是必要的，以分层患者和指导治疗。分析了一组16名接受13NH3 PET和CCTA的低风险CAD受试者。图像融合技术被用来对齐研究和CTA衍生的解剖结构，用于识别冠状动脉轨迹。通过标准血管区域和沿着从心脏底部到心尖的患者特定血管路径的1组织隔室模型计算MBF。MBF的低风险范围。计算了整个队列的LAD、LCX和rPDA的MFR和RFR，并按性别分开。计算的低风险范围用于评估疑似CAD的前瞻性患者。我们的血管特异性功能指数和3D显示有望更接近地复制导管插入术期间通常进行的操作，并有可能为识别血流限制性病变和图像引导治疗提供有效的非侵入性工具。
The goal of the present work is to present a novel methodology for the extraction of MBF, MFR and RFR along coronary arteries by means of multimodality image fusion of dynamic PET and CCTA images. FFR is the reference standard to identify flow-limiting lesions, but its invasiveness limits broad application. New noninvasive methodologies are warranted to stratify patients and guide treatment. A group of 16 low-risk CAD subjects who underwent both 13NH3 PET and CCTA were analyzed. Image fusion techniques were employed to align the studies and CCTA-derived anatomy used to identify coronaries trajectories. MBF was calculated by means of a 1-tissue compartmental model for the standard vascular territories and along patient-specific vessel paths from the base to the apex of the heart. Low-risk ranges for MBF. MFR and RFR for LAD, LCX and rPDA were computed for the entire cohort and separated by gender. Computed low-risk ranges were used to assess a prospective patient with suspected CAD. Our vessel-specific functional indexes and 3D displays offer promise to more closely replicate what is commonly performed during a catheterization session and have the potential of providing effective noninvasive tools for the identification of flow-limiting lesions and image-guided therapy.
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影响因子：
14
作者：
Sdringola, Stefano;Johnson, Nils P.;Gould, K. Lance
通讯作者：
Gould, K. Lance
影响因子：
2.4
作者：
Piccinelli, Marina;Santana, Cesar;Garcia, Ernest, V
通讯作者：
Garcia, Ernest, V
影响因子：
7.5
作者：
Stuijfzand, Wijnand J.;Uusitalo, Valtteri;Knaapen, Paul
通讯作者：
Knaapen, Paul
影响因子：
14
作者：
Schindler, Thomas H.;Schelbert, Heinrich R.;Dilsizian, Vasken
通讯作者：
Dilsizian, Vasken
影响因子：
4.5
作者：
Cury, Ricardo C.;Abbara, Suhny;Leipsic, Jonathon A.
通讯作者：
Leipsic, Jonathon A.