Finite Element Analysis of Tricuspid Valve Deformation from Multi-slice Computed Tomography Images.
Finite Element Analysis of Tricuspid Valve Deformation from Multi-slice Computed Tomography Images.
复制标题
来自多板计算机断层扫描图像的三尖瓣变形的有限元分析。
DOI：
10.1007/s10439-018-2024-8
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发表时间：
2018-08
影响因子：
3.8
通讯作者：
Sun W
中科院分区：
文献类型：
--
作者：
Kong F;Pham T;Martin C;McKay R;Primiano C;Hashim S;Kodali S;Sun W
尽管临床上对三尖瓣的研究越来越多，但人们对三尖瓣生物力学的认识尚不完全，而生物力学对三尖瓣的正常功能和成功的修复技术具有重要意义。具有患者特定人体TV几何形状的计算模型可以提供对TV生物力学的定量理解。因此，本研究旨在从多层计算机断层扫描(MSCT)图像建立人体电视的有限元(FE)模型，以研究脊索力和叶的应力和应变。从MSCT图像中获取健康TV的人体受试者建立了三个有限元模型，其中包含了详细的叶几何形状、真实的人体TV的非线性各向异性超弹性材料特性以及从MSCT图像跟踪的生理边界条件。模拟电视从舒张期到收缩期的关闭过程。反复调整弦的长度，直到模拟的电视几何图形与从收缩时MSCT图像重建的“真实”几何图形很好地一致。鼓索(或基索)上的弦向力大于粗带弦，鼓索对前乳头肌的总作用力大于后乳头肌或隔乳头肌。在峰值收缩压时，瓣叶中部的平均最大应力为30~90kPa，平均最大主应变值为0.16~0.30。健康电视的结果可以作为电视力学的基础生物力学指标，并可用于电视修复器的设计。开发的计算方法可能是朝着开发计算模型的方向迈出的一步，该计算模型可能支持未来复杂的电视维修程序的术前规划。
Despite the growing clinical interest in the tricuspid valve (TV), there is an incomplete understanding of TV biomechanics which is important in normal TV function and successful TV repair techniques. Computational models with patient-specific human TV geometries can provide a quantitative understanding of TV biomechanic. Therefore, this study aimed to develop finite element (FE) models of human TVs from multi-slice computed tomography (MSCT) images to investigate chordal forces and leaflet stresses and strains. Three FE models were constructed for human subjects with healthy TVs from MSCT images and incorporated detailed leaflet geometries, realistic nonlinear anisotropic hyperelastic material properties of human TV, and physiological boundary conditions tracked from MSCT images. TV closure from diastole to systole was simulated. Chordal lengths were iteratively adjusted until the simulated TV geometries were in good agreement with the “true” geometries reconstructed from MSCT images at systole. Larger chordal forces were found on the strut (or basal) chords than on the rough zone chords and the total forces applied on the anterior papillary muscles by the strut chords were higher than those on the posterior or septal papillary muscles. At peak systolic pressure, the average maximum stress on the middle sections of the leaflets ranged from 30–90 kPa, while the average maximum principal strain values ranged from 0.16 to 0.30. The results from healthy TVs can serve as baseline biomechanical metrics of TV mechanics and may be used to inform TV repair device design. The computational approach developed could be one step towards developing computational models that may support pre-operative planning in complex TV repair procedures in the future.
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影响因子：
4.9
作者：
Martin, Caitlin;Sun, Wei
通讯作者：
Sun, Wei
DOI：
10.1080/10255842.2015.1118467
发表时间：
2016
影响因子：
1.6
作者：
Liu H;Sun W
通讯作者：
Sun W
影响因子：
3.9
作者：
Liang, Liang;Liu, Minliang;Sun, Wei
通讯作者：
Sun, Wei
影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW
影响因子：
37.8
作者：
Fukuda, Shota;Saracino, Giuseppe;Shiota, Takahiro
通讯作者：
Shiota, Takahiro