Delayed exercise promotes remodeling in sub-rupture fatigue damaged tendons.
Delayed exercise promotes remodeling in sub-rupture fatigue damaged tendons.
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DOI：
10.1002/jor.22856
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发表时间：
2015-06
影响因子：
2.8
通讯作者：
Andarawis-Puri, N.
中科院分区：
文献类型：
--
作者：
Bell, R.;Boniello, M. R.;Gendron, N. R.;Flatow, E. L.;Andarawis-Puri, N.
肌腱病是一种常见的肌肉骨骼损伤，其治疗受到无效治疗措施的限制。以前我们已经证明肌腱不能有效地修复早期亚断裂疲劳损伤。相比之下，生理运动已被证明可以促进健康肌腱的重塑，但其作为治疗手段促进疲劳损伤肌腱修复的有效性仍不清楚。因此，这项研究的目的是评估疲劳损伤发生后1天和14天开始的运动对促进疲劳损伤肌腱的结构修复的有效性。我们假设，疲劳负荷后14天开始的运动将促进重塑，表现为胶原基质损伤面积减少，I型前胶原和核心蛋白增加，而肌腱病变指示蛋白减少。从疲劳负荷后1d或14d开始，进行6周30min/d或60min/d的运动。疲劳损伤发生后1天开始运动会导致基质损伤加重，尤其是在肌腱附着处。在疲劳损伤发生后14天开始运动，导致中间物质受损区域的重塑和附着点胶原的合成。在最初对损伤的生物反应减弱后进行的生理运动可能会促进受损肌腱的重塑。
Tendinopathy is a common musculoskeletal injury whose treatment is limited by ineffective therapeutic interventions. Previously we have shown that tendons ineffectively repair early sub-rupture fatigue damage. In contrast, physiological exercise has been shown to promote remodeling of healthy tendons but its utility as a therapeutic to promote repair of fatigue damaged tendons remains unknown. Therefore, the objective of this study was to assess the utility of exercise initiated 1 and 14 days after onset of fatigue damage to promote structural repair in fatigue damaged tendons. We hypothesized that exercise initiated 14 days after fatigue loading would promote remodeling as indicated by a decrease in area of collagen matrix damage, increased procollagen I and decorin, while decreasing proteins indicative of tendinopathy. Rats engaged in 6-week exercise for 30 min/day or 60 min/day starting 1 or 14 days after fatigue loading. Initiating exercise 1-day after onset of fatigue injury led to exacerbation of matrix damage, particularly at the tendon insertion. Initiating exercise 14 days after onset of fatigue injury led to remodeling of damaged regions in the midsubstance and collagen synthesis at the insertion. Physiological exercise applied after the initial biological response to injury has dampened can potentially promote remodeling of damaged tendons.
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DOI：
10.1002/jor.20722
发表时间：
2009-02
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Fung DT;Wang VM;Laudier DM;Shine JH;Basta-Pljakic J;Jepsen KJ;Schaffler MB;Flatow EL
通讯作者：
Flatow EL
影响因子：
2.8
作者：
Andarawis-Puri, Nelly;Sereysky, Jedd B.;Flatow, Evan L.
通讯作者：
Flatow, Evan L.
影响因子：
2.4
作者：
Fung, David T.;Wang, Vincent M.;Andarawis-Puri, Nelly;Basta-Pljakic, Jelena;Li, Yonghui;Laudier, Damien M.;Sun, Hui B.;Jepsen, Karl J.;Schaffler, Mitchell B.;Flatow, Evan L.
通讯作者：
Flatow, Evan L.
影响因子：
2.8
作者：
Andarawis-Puri, Nelly;Philip, Anaya;Laudier, Damien;Schaffler, Mitchell B.;Flatow, Evan L.
通讯作者：
Flatow, Evan L.
影响因子：
6.9
作者：
Samiric, Tom;Parkinson, John;Handley, Christopher J.
通讯作者：
Handley, Christopher J.