Multiple Oncogene Activation in a Radiation Carcinogenesis Model
Multiple Oncogene Activation in a Radiation Carcinogenesis Model
复制标题
辐射致癌模型中的多个癌基因激活
DOI：
10.1007/978-1-4615-6462-1_51
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
T. Ashkenazi
中科院分区：
文献类型：
--
作者：
S. Garte;M. Sawey;F. Burns;M. Felber;T. Ashkenazi
辐射是研究最彻底的环境致癌剂，而癌症诱导是辐射最显着的晚期效应。电离辐射会在 DNA 中造成许多损伤，包括碱基修饰、单链和双链断裂以及糖损伤。辐射诱发的体细胞突变很大一部分与染色体缺失和基因重排有关。这些改变是染色体断裂导致遗传物质丢失（缺失）或断裂染色体重新连接（重排）的结果 (l)。还发现辐射是某些模型测定系统中的点诱变剂。辐射的这些基因毒性效应与辐射致癌的分子机制之间的关系尚不清楚。我们决定使用当前涉及癌基因激活的分子概念来解决这个问题，该概念应用于生物学上明确的电离辐射大鼠皮肤癌变实验模型。局部暴露于单剂量或分次剂量的电离辐射后，大鼠皮肤会出现多种类型的肿瘤 (2)，其中包括鳞状细胞癌、基底细胞癌、肉瘤、透明细胞癌和皮脂细胞瘤。肿瘤的组织学类型大概反映了起源的细胞类型。
Radiation is the most thoroughly studied environmental carcinogenic agent and cancer induction is the most significant late effect of radiation. Ionizing radiation creates a number of lesions in DNA including base modification, single and double strand breaks, and sugar damage. A significant proportion of the radiation-induced mutations in somatic cells are associated with chromosomal deletions and gene rearrangements. These alterations are the result of breakage of the chromosomes followed by loss of genetic material (deletions) or rejoining of broken chromosomes (rearrangements) (l). Radiation has also been found to be a point mutagen in certain model assay systems. The relationship of these geno-toxic effects of radiation to molecular mechanisms of radiation carcinogenesis is not yet understood. We have decided to address this issue using current molecular concepts involving oncogene activation applied to the biologically well-defined experimental model of rat skin carcinogenesis by ionizing radiation. Several types of tumors develop in rat skin following localized exposure to single or fractionated doses of ionizing radiation (2) which include squamous cell carcinomas, basal cell carcinomas, sarcomas, clear cell carcinomas, and sebaceous cell tumors. The histologic type of the tumor presumably reflects the cell type of origin.
电离辐射诱导的原发性大鼠肿瘤中 c-myc 和 c-K-ras 癌基因的激活。
影响因子：
5.3
作者：
Sawey,MJ;Hood,AT;Burns,FJ;Garte,SJ
通讯作者：
Garte,SJ
直接作用烷化剂激活转化基因的致癌特异性。
影响因子：
4.7
作者：
Garte,SJ;Hood,AT;Hochwalt,AE;D'Eustachio,P;Snyder,CA;Segal,A;Albert,RE
通讯作者：
Albert,RE