A hyper-connected but less efficient small-world network in the substance-dependent brain.
A hyper-connected but less efficient small-world network in the substance-dependent brain.
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DOI：
10.1016/j.drugalcdep.2015.04.015
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发表时间：
2015-07-01
影响因子：
4.2
通讯作者：
Childress, Anna Rose
中科院分区：
文献类型：
--
作者：
Wang, Ze;Suh, Jesse;Li, Zhengjun;Li, Yin;Franklin, Teresa;O'Brien, Charles;Childress, Anna Rose
成瘾者大脑的功能相互联系可能在重要方面不同于非成瘾者，但以前的分析方法通常仅限于研究少数选定的大脑区域之间的联系。最近的方法使得能够检查整个大脑内的大量功能性相互作用，即功能性连接体（FCM）。本研究的目的是使用静息态功能磁共振成像（rsfMRI）表征成瘾的FCM改变，并评估其与成瘾相关症状的关系。从20名主要诊断为可卡因依赖（DRUG）的慢性多种药物使用者和19名年龄匹配的非药物使用健康对照（CTL）中获得rsfMRI数据。FCM使用图论分析进行评估。在评估的90个脑分区中，DRUG显示出更强的功能连接。在控制功能连接差异和由此产生的网络密度后，DRUG表现出降低的通信效率和降低的小世界性。吸毒者大脑中连接强度的增加表明了一种提高的动态静息状态，这种状态可能使快速、半自动地执行针对毒品相关目标的行为成为可能。FCM通信效率的降低和小世界性的降低表明正常的区域间通信和拓扑特征的丧失，使得难以抑制药物寻求行为。
The functional interconnections of the addicted brain may differ from the non-addicted population in important ways, but prior analytic approaches were usually limited to the study of connections between a few number of selected brain regions. Recent approaches enable examination of the vast functional interactions within the entire brain, the functional connectome (FCM). The purpose of this study was to characterize FCM alterations in addiction using resting state functional Magnetic Resonance Imaging (rsfMRI) and to assess their relations to addiction-related symptoms. rsfMRI data were acquired from 20 chronic polydrug users whose primary diagnosis was cocaine dependence (DRUG) and 19 age-matched non-drug using healthy controls (CTL). FCM was assessed using graph theoretical analysis. Among the assessed 90 brain subdivisions, DRUG showed stronger functional connectivity. After controlling functional connectivity difference and the resultant network density, DRUG showed reduced communication efficiency and reduced small-worldness. The increased connection strength in drug users’ brain suggests an elevated dynamic resting state that may enable a rapid, semi-automatic, execution of behaviors directed toward drug-related goals. The reduced FCM communication efficiency and reduced small-worldness suggest a loss of normal inter-regional communications and topology features that makes it difficult to inhibit the drug seeking behavior.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
--
作者：
Hong, L. Elliot;Gu, Hong;Yang, Yihong;Ross, Thomas J.;Salmeron, Betty Jo;Buchholz, Brittany;Thaker, Gunvant K.;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
影响因子：
3.7
作者：
Humphries MD;Gurney K
通讯作者：
Gurney K
影响因子：
6.7
作者：
Lindsey, Kimberly P;Gatley, S John;Volkow, Nora D
通讯作者：
Volkow, Nora D
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T