Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuits.
Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuits.
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DOI：
10.1001/archgenpsychiatry.2009.2
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发表时间：
2009-04
影响因子：
--
通讯作者：
Stein, Elliot A.
中科院分区：
文献类型：
--
作者：
Hong, L. Elliot;Gu, Hong;Yang, Yihong;Ross, Thomas J.;Salmeron, Betty Jo;Buchholz, Brittany;Thaker, Gunvant K.;Stein, Elliot A.
了解尼古丁成瘾的潜在机制，以开发更有效的治疗方法，是公共卫生的优先事项。研究一致表明，尼古丁能短暂地改善多种认知功能。然而，使用尼古丁替代品治疗尼古丁成瘾通常产生不一致的结果。虽然这种二分法是众所周知的，但其原因尚不清楚。影像学研究表明，尼古丁的挑战几乎总是涉及扣带皮层，这表明该基因座可能是与尼古丁成瘾及其治疗相关的关键区域。确定与尼古丁成瘾程度相关的扣带功能回路并研究尼古丁是如何影响它们的。采用双盲、安慰剂对照设计，利用区域特异性静息状态fMRI信号提取静息状态扣带功能连接，并研究尼古丁成瘾和急性尼古丁给药如何调节这些功能通路。门诊诊所。19名健康吸烟者。单剂量（21/35mg）尼古丁贴片。尼古丁成瘾严重程度与扣带静息状态功能连接的相关性及急性尼古丁对连接强度的影响。发现了与尼古丁成瘾和尼古丁作用相关的明显分离的通路。尼古丁成瘾的严重程度与背前扣带皮层（dACC）纹状体回路的强度有关，尼古丁贴片不改变该回路。相反，急性尼古丁增强扣带-新皮质功能连接模式。尼古丁成瘾与连接dACC和纹状体的功能回路密切相关。急性给药尼古丁对这些神经回路没有显著影响。相反，尼古丁增强了几个扣带-新皮层功能连接回路，这与尼古丁成瘾的严重程度无关，但可能在尼古丁的认知增强特性中发挥作用。静息状态dacc -纹状体功能连接可能是尼古丁成瘾的回路水平生物标志物，旨在增强dacc -纹状体功能通路的新疗法的开发可能有效治疗尼古丁成瘾。
Understanding the mechanisms underlying nicotine addiction in order to develop more effective treatment is a public health priority. Research consistently shows that nicotine transiently improves multiple cognitive functions. However, using nicotine replacement to treat nicotine addiction yields generally inconsistent results. While this dichotomy is well known, the reasons are unclear. Imaging studies showed that nicotine challenges almost always involve cingulate cortex, suggesting that this loci may be a key region associated with nicotine addiction and its treatment. To identify cingulate functional circuits that are associated with the severity of nicotine addiction and to study how nicotine affects them. Using region-specific resting-state fMRI signals to extract resting-state cingulate functional connectivity, and to study how nicotine addiction and acute nicotine administration modulate these functional pathways, in a double-blind, placebo-controlled design. Outpatient clinics. Nineteen healthy smokers. Single dose (21/35mg) nicotine patch. Correlation of nicotine addiction severity and cingulate resting state functional connectivity, and effects of acute nicotine on connectivity strength. Clearly separated pathways that correlated with nicotine addiction vs. nicotinic action were found. The severity of nicotine addiction was associated with the strength of dorsal anterior cingulate cortex (dACC)-striatal circuits, which were not modified by nicotine patch administration. In contrast, acute nicotine enhanced cingulate-neocortical functional connectivity patterns. Nicotine addiction was strongly associated with functional circuits interconnecting dACC and the striatum. Acute nicotine administration had no significant effect on these circuits. Rather, nicotine enhanced several cingulate-neocortical functional connectivity circuits that were not associated with the severity of nicotine addiction, but may play a role in nicotine's cognitive enhancing properties. Resting state dACC-striatum functional connectivity may serve as a circuit-level biomarker for nicotine addiction, and the development of new therapeutics aiming to enhance the dACC-striatum functional pathways may be effective for nicotine addiction treatment.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Kumari, V;Gray, JA;Sharma, T
通讯作者：
Sharma, T
影响因子：
3.2
作者：
Giessing, C.;Fink, G. R.;Thiel, C. M.
通讯作者：
Thiel, C. M.
影响因子：
2.9
作者：
GRUNWALD, F;SCHROCK, H;KUSCHINSKY, W
通讯作者：
KUSCHINSKY, W
影响因子：
6
作者：
HUGHES, JR;HIGGINS, ST;BICKEL, WK
通讯作者：
BICKEL, WK