The diverse functions of the DEG/ENaC family: linking genetic and physiological insights.
The diverse functions of the DEG/ENaC family: linking genetic and physiological insights.
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DOI：
10.1113/jp283335
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发表时间：
2023-05
影响因子：
5.5
通讯作者：
Walker, Denise S.
中科院分区：
文献类型：
--
作者：
Kaulich, Eva;Grundy, Laura J.;Schafer, William R.;Walker, Denise S.
离子通道的DEG/ENaC家族是基于来自秀丽隐杆线虫的退化蛋白（DEG）与哺乳动物上皮钠通道（ENaC）亚基之间的序列相似性定义的，并且还包括来自动物门的各种非电压门控阳离子通道，包括哺乳动物酸敏感离子通道（ASIC）和果蝇扒手。ENaC和ASIC具有广泛的医学重要性;例如，ENaC在呼吸和肾功能中起重要作用，而ASIC在缺血和炎性疼痛中起重要作用，以及与记忆和学习有关。电生理学方法，在体外和体内，在建立这个不同的家庭的生理特性，确定一系列的调制器，并暗示他们在广泛的细胞功能，包括机械感觉，酸感觉和突触调制中发挥了重要作用。同样，无脊椎动物和脊椎动物的遗传研究在将我们对通道特性的理解与细胞和整个动物/行为水平的功能联系起来方面发挥了重要作用。将遗传和生理学证据结合在一起对于进一步了解DEG/ENaC通道的精确细胞作用至关重要，家族成员之间的多样性允许比较生理学研究来剖析这些不同功能的分子基础。 摘要图例在一系列动物中，影响DEG/ENaC功能（蓝色箭头）的各种调节剂和刺激物以及它们所涉及的各种功能（绿色箭头）的示意图，以所描绘的动物为例。由Biorender.com创建。
The DEG/ENaC family of ion channels was defined based on the sequence similarity between degenerins (DEG) from the nematode Caenorhabditis elegans and subunits of the mammalian epithelial sodium channel (ENaC), and also includes a diverse array of non‐voltage‐gated cation channels from across animal phyla, including the mammalian acid‐sensing ion channels (ASICs) and Drosophila pickpockets. ENaCs and ASICs have wide ranging medical importance; for example, ENaCs play an important role in respiratory and renal function, and ASICs in ischaemia and inflammatory pain, as well as being implicated in memory and learning. Electrophysiological approaches, both in vitro and in vivo, have played an essential role in establishing the physiological properties of this diverse family, identifying an array of modulators and implicating them in an extensive range of cellular functions, including mechanosensation, acid sensation and synaptic modulation. Likewise, genetic studies in both invertebrates and vertebrates have played an important role in linking our understanding of channel properties to function at the cellular and whole animal/behavioural level. Drawing together genetic and physiological evidence is essential to furthering our understanding of the precise cellular roles of DEG/ENaC channels, with the diversity among family members allowing comparative physiological studies to dissect the molecular basis of these diverse functions. Abstract figure legend Schematic illustration of the diverse modulators and stimuli that influence DEG/ENaC function (blue arrows) and the diverse range of functions in which they have been implicated (green arrows), in an array of animals, exemplified by those depicted. Created with Biorender.com.
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