Postnatal Development of Microglia-Like Cells in Mouse Cochlea.
Postnatal Development of Microglia-Like Cells in Mouse Cochlea.
复制标题
小鼠耳蜗小胶质细胞样细胞的产后发育
DOI：
10.1155/2018/1970150
复制
发表时间：
2018
影响因子：
3.1
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Chen P;Chai Y;Liu H;Li G;Wang L;Yang T;Wu H
小胶质细胞参与中枢神经系统的监视和清洁。最近，小胶质细胞样细胞（MLC）已被发现在成人耳蜗和研究其在耳蜗炎症的作用。然而，MLCs在耳蜗发育过程中的存在和潜在作用仍不清楚。在这项研究中，使用MLC特异性标记物IBA 1进行免疫染色，以表征发育中耳蜗中MLC的存在、分布和形态。从P0到P14，MLCs出现在耳蜗的各个区域，包括蜗轴、螺旋板、螺旋神经节、螺旋韧带和Corti器。有趣的是，小鼠耳蜗中MLCs的总数自P0以来稳步增加，在P5达到峰值，然后从P5到P14逐渐减少。在耳蜗螺旋韧带中，MLCs的分布有从I/II型纤维细胞富集区向III/IV型纤维细胞富集区转移的趋势，并伴随着MLCs形态的变化，即从激活的变形样形态向静止的分枝状形态转变。我们的研究结果表明，MLCs在出生后耳蜗发育过程中经历了剧烈的形态和分布变化，这可能在耳蜗的成熟和重塑中发挥作用。
Microglial cells are involved in surveillance and cleaning of the central nervous system. Recently, microglial-like cells (MLC) have been found in an adult cochlea and investigated for their role in cochlear inflammation. The presence and potential roles of MLCs during the development of the cochlea, however, remain unclear. In this study, immunostaining was performed using the MLC-specific marker IBA1 to characterize the presence, distribution, and morphology of MLCs in the developing cochlea. From P0 to P14, MLCs were present in a variety of cochlear regions including the modiolus, spiral lamina, spiral ganglion, spiral ligament, and the organ of Corti. Interestingly, the overall number of MLCs in a mouse cochlea steadily increased since P0, peaks at P5, then gradually decreased from P5 to P14. In the spiral ligament, the distribution of the MLCs trends to shift from the type I/II fibrocyte-rich regions to the type III/IV fibrocyte-rich regions during the course of cochlear development, accompanied by the morphological changes of MLCs from the amoeboid, activated form to the ramified, quiescent form. Our results suggested that MLCs experience drastic morphological and distributional changes during postnatal cochlear development, which may play a role in the maturing and remodeling of the cochlea.
登录
查看更多内容
Wnt 激活可防止新霉素诱导的小鼠耳蜗毛细胞损伤
影响因子：
9
作者：
Liu L;Chen Y;Qi J;Zhang Y;He Y;Ni W;Li W;Zhang S;Sun S;Taketo MM;Wang L;Chai R;Li H
通讯作者：
Li H
骨形态发生蛋白4促进体外流式分选Bhlhb5耳蜗螺旋神经节神经元的存活并保留其结构
影响因子：
4.6
作者：
Waqas M;Sun S;Xuan C;Fang Q;Zhang X;Islam IU;Qi J;Zhang S;Gao X;Tang M;Shi H;Li H;Chai R
通讯作者：
Chai R
影响因子：
56.9
作者：
Nimmerjahn, A;Kirchhoff, F;Helmchen, F
通讯作者：
Helmchen, F
影响因子：
2.5
作者：
Lang, HN;Ebihara, Y;Schulte, BA
通讯作者：
Schulte, BA
影响因子：
5.7
作者：
Kelly MC;Chen P
通讯作者：
Chen P