Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways.
Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways.
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DOI：
10.4049/jimmunol.1101392
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发表时间：
2011-12-15
期刊：
影响因子：
--
通讯作者：
Gause WC
中科院分区：
文献类型：
--
作者：
Mishra PK;Wu W;Rozo C;Hallab NJ;Benevenia J;Gause WC
关节置换术中的磨损碎屑被认为是相关组织损伤性炎症的原因。在这项研究中，我们研究了是否固体钛微粒（mTi）的足够大小的积累作为磨损碎屑可以刺激先天性或适应性免疫在体内。mTi与OVA联合给药可促进血清IgE和IgG 1的总升高和Ag特异性升高。对转移的转基因OVA特异性幼稚T细胞的分析进一步表明，mTi作为佐剂在体内驱动Ag特异性Th 2细胞分化。先天性反应的评估表明，mTi诱导快速招募和分化的替代激活的巨噬细胞在体内，通过IL-4和TLR-4的独立途径。这些研究表明，单独的固体微粒可以作为佐剂诱导有效的先天性和适应性Th 2型免疫应答，并进一步表明关节置换中的磨损碎屑可能引发Th 2型炎症特性。
Wear debris in joint replacements has been suggested as a cause of associated tissue damaging inflammation. In this study, we examined whether solid Titanium micro-particles (mTi) of sufficient size to accumulate as wear debris could stimulate innate or adaptive immunity in vivo. mTi, administered in conjunction with OVA, promoted total and Ag-specific elevations in serum IgE and IgG1. Analysis of transferred transgenic OVA-specific naïve T cells further showed that mTi acted as an adjuvant to drive Ag-specific Th2 cell differentiation in vivo. Assessment of the innate response indicated that mTi induced rapid recruitment and differentiation of alternatively activated macrophages in vivo, through IL-4 and TLR-4 independent pathways. These studies suggest that solid micro-particles alone can act as adjuvants to induce potent innate and adaptive Th2-type immune responses and further suggest that wear debris in joint replacements may trigger Th2-type inflammatory properties.
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影响因子：
4.1
作者：
Kanaji, Arihiko;Caicedo, Marco S.;Virdi, Amarjit S.;Sumner, D. Rick;Hallab, Nadim J.;Sena, Kotaro
通讯作者：
Sena, Kotaro
影响因子：
82.9
作者：
Flach, Tracy L.;Ng, Gilbert;Shi, Yan
通讯作者：
Shi, Yan
影响因子：
5.4
作者：
Franchi, Luigi;Nunez, Gabriel
通讯作者：
Nunez, Gabriel
DOI：
10.1126/science.1183021
发表时间：
2010-01-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Iwasaki A;Medzhitov R
通讯作者：
Medzhitov R
影响因子：
2.8
作者：
Islam, Andrew S.;Beidelschies, Michelle A.;Huml, Anne;Greenfield, Edward M.
通讯作者：
Greenfield, Edward M.