High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men.
High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men.
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DOI：
10.1016/j.atherosclerosis.2015.01.031
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发表时间：
2015-04
期刊：
影响因子：
5.3
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Zaid, Maryam;Fujiyoshi, Akira;Miura, Katsuyuki;Abbott, Robert D.;Okamura, Tomonori;Takashima, Naoyuki;Torii, Sayuki;Saito, Yoshino;Hisamatsu, Takashi;Miyagawa, Naoko;Ohkubo, Takayoshi;Kadota, Aya;Sekikawa, Akira;Maegawa, Hiroshi;Nakamura, Yasuyuki;Mitsunami, Kenichi;Ueshima, Hirotsugu
关键词：
高密度脂蛋白颗粒（HDL-P）与动脉粥样硬化的相关性可能比高密度脂蛋白胆固醇（HDL-C）更强，并且独立于传统的心血管危险因素。这种关联是否在低风险冠心病人群中持续存在尚不清楚。本研究在日本男性中调查了HDL-P和HDL-C与颈动脉内膜-中膜厚度（cIMT）和斑块数量的关系，日本男性的特点是HDL-C水平高于西方人群，冠心病负担较低。我们对870名年龄在40-79岁之间、无已知临床心血管疾病（CVD）且未服用降脂药物的日本男性进行了横断面调查。参与者是在居住在日本滋贺草津市的日本人中随机选择的。在校正了传统冠心病危险因素（包括低密度脂蛋白胆固醇（LDL-C）和糖尿病）的模型中，HDL-P和HDL-C均与cIMT呈独立负相关。在进一步调整HDL-C后，HDL-P与cIMT保持相关性（P<0.01），而在模型中纳入HDL-P后，HDL-C与cIMT的相关性明显缺失。在颈动脉斑块计数中，HDL-P与斑块计数的减少显著相关，而HDL-C则没有。一项针对日本男性的横断面研究显示，与HDL-C相比，HDL-P与颈动脉粥样硬化的相关性更强。研究结果表明，HDL-P与亚临床动脉粥样硬化密切相关，即使在冠心病低风险人群中也是如此。
The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P<0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.
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影响因子：
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通讯作者：
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影响因子：
5.4
作者：
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O'Leary DH