Receptor-targeted nanocarriers for therapeutic delivery to cancer.
Receptor-targeted nanocarriers for therapeutic delivery to cancer.
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DOI：
10.3109/09687688.2010.521200
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发表时间：
2010-10
影响因子：
--
通讯作者：
Lee RJ
中科院分区：
文献类型：
--
作者：
Yu B;Tai HC;Xue W;Lee LJ;Lee RJ
有效和特定部位的治疗药物输送是癌症临床治疗中的一个关键挑战。纳米载体，如脂质体、胶束和聚合物纳米粒，已被研究通过各种机制来改善治疗药物的生物利用度和药代动力学性质，例如增强渗透性和滞留(EPR)效应。通过将靶向配体连接到纳米载体上以实现对肿瘤细胞或肿瘤血管系统的选择性递送，可能会实现进一步的改进。事实上，受体靶向的纳米载体递送已经被证明在体外和体内都能改善治疗反应。人们已经研究了多种配体，包括叶酸、转铁蛋白、抗体、多肽和适配子。可以将多种功能整合到纳米颗粒的设计中，例如，实现成像和触发细胞内药物释放。本文主要介绍了靶向纳米载体的最新研究进展，并将介绍多靶向、多功能纳米粒子等新概念。
Efficient and site-specific delivery of therapeutic drugs is a critical challenge in clinical treatment of cancer. Nano-sized carriers such as liposomes, micelles, and polymeric nanoparticles have been investigated for improving bioavailability and pharmacokinetic properties of therapeutics via various mechanisms, for example, the enhanced permeability and retention (EPR) effect. Further improvement can potentially be achieved by conjugation of targeting ligands onto nanocarriers to achieve selective delivery to the tumour cell or the tumour vasculature. Indeed, receptor-targeted nanocarrier delivery has been shown to improve therapeutic responses both in vitro and in vivo. A variety of ligands have been investigated including folate, transferrin, antibodies, peptides and aptamers. Multiple functionalities can be incorporated into the design of nanoparticles, e.g., to enable imaging and triggered intracellular drug release. In this review, we mainly focus on recent advances on the development of targeted nanocarriers and will introduce novel concepts such as multi-targeting and multi-functional nanoparticles.
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影响因子：
17.1
作者：
Bhirde, Ashwin A.;Patel, Vyomesh;Gavard, Julie;Zhang, Guofeng;Sousa, Alioscka A.;Masedunskas, Andrius;Leapman, Richard D.;Weigert, Roberto;Gutkind, J. Silvio;Rusling, James F.
通讯作者：
Rusling, James F.
影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
4.7
作者：
Beuttler, Julia;Rothdiener, Miriam;Kontermann, Roland E.
通讯作者：
Kontermann, Roland E.
影响因子：
10.8
作者：
Boddapati, Sarathi V.;D'Souza, Gerard G. M.;Weissig, Volkmar
通讯作者：
Weissig, Volkmar
影响因子：
3.7
作者：
Chang DK;Lin CT;Wu CH;Wu HC
通讯作者：
Wu HC