Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response.
Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response.
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DOI：
10.1016/j.jagp.2013.01.013
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Weiner MW
中科院分区：
文献类型：
--
作者：
Mackin RS;Tosun D;Mueller SG;Lee JY;Insel P;Schuff N;Truran-Sacrey D;Arean P;Nelson JC;Weiner MW
皮质萎缩与晚年抑郁症（LLD）有关，最近的研究结果表明，右半球皮质厚度减少与重度抑郁症的家族性风险有关，但LLD的皮质厚度异常尚未被探索。此外，皮质萎缩被认为是LLD患者抗抑郁治疗反应差的一个因素，但皮质厚度对心理治疗反应的影响尚不清楚。本研究旨在评估LLD的皮质厚度模式及其与心理治疗结果的关系。参与者包括22名LLD患者和12名年龄匹配的对照受试者。LLD参与者完成了12周的心理治疗，治疗反应被定义为抑郁症状减少50%。所有参与者均参与了脑磁共振成像（MRI）和皮层灰质组织厚度的绘制。LLD个体在右侧额叶、顶叶和颞叶脑区表现出比对照组更薄的皮层。11名参与者（50%）在治疗12周后表现出积极的心理治疗反应。与治疗应答者相比，心理治疗无应答者表现出双侧后扣带和海马旁皮质、左侧中央旁皮质、楔叶前皮质、岛状皮质以及右侧内侧眶额皮质和外侧枕皮质较薄。我们的研究结果表明，LLD的右半球皮层异常比以前报道的要多。此外，我们的研究结果表明，双侧皮质厚度减少可能是心理治疗反应不良风险较高的个体的重要表型标志。
Cortical atrophy has been associated with late life depression (LLD) and recent findings suggest that reduced right hemisphere cortical thickness is associated with familial risk for major depressive disorder but cortical thickness abnormalities in LLD have not been explored. Further, cortical atrophy has been posited as a contributor to poor antidepressant treatment response in LLD but the impact of cortical thickness on psychotherapy response is unknown. This study was conducted to evaluate patterns of cortical thickness in LLD and in relation to psychotherapy treatment outcomes. Participants included 22 individuals with LLD and 12 age matched comparison subjects. LLD participants completed 12 weeks of psychotherapy and treatment response was defined as a 50% reduction in depressive symptoms. All participants participated in Magnetic Resonance Imaging (MRI) of the brain and cortical mapping of grey matter tissue thickness was calculated. LLD individuals demonstrated thinner cortex than controls prominently in the right frontal, parietal, and temporal brain regions. Eleven participants (50%) exhibited positive psychotherapy response after 12 weeks of treatment. Psychotherapy non-responders demonstrated thinner cortex in bilateral posterior cingulate and parahippocampal cortices, left paracentral, precuneus, cuneus, and insular cortices, and the right medial orbito-frontal and lateral occipital cortices relative to treatment responders. Our findings suggest more distributed right hemisphere cortical abnormalities in LLD than have been previously reported. Additionally, our findings suggest that reduced bilateral cortical thickness may be an important phenotypic marker of individuals at higher risk for poor response to psychotherapy.
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影响因子：
--
作者：
Bell-McGinty, S;Lopez, OL;Becker, JT
通讯作者：
Becker, JT
影响因子：
10.6
作者：
Lai, TJ;Payne, ME;Krishnan, KRR
通讯作者：
Krishnan, KRR
影响因子：
5.9
作者：
AREAN, PA;PERRI, MG;JOSEPH, TX
通讯作者：
JOSEPH, TX
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
7.2
作者：
Anstey, Kaarin J.;von Sanden, Chwee;Luszcz, Mary A.
通讯作者：
Luszcz, Mary A.