Food deprivation increases brain nitric oxide synthase and depresses brain serotonin levels in rats
Food deprivation increases brain nitric oxide synthase and depresses brain serotonin levels in rats
复制标题
食物匮乏会增加大鼠大脑一氧化氮合酶并降低大脑血清素水平
DOI：
10.1016/0028-3908(94)90100-7
复制
发表时间：
1994
影响因子：
4.7
通讯作者：
A. Caputi
中科院分区：
文献类型：
--
作者：
F. Squadrito;G. Calapai;D. Altavilla;D. Cucinotta;B. Zingarelli;G. Campo;V. Arcoraci;L. Sautebin;G. Mazzaglia;A. Caputi
We studied nitric oxide (NO) synthase activity and serotonin content in the diencephalon of 24 hr food deprived rats. NO synthase activity was significantly increased whereas serotonin levels together with those of tryptophan and 5-hydroxyindoleacetic acid (5-HIAA) were reduced in food deprived rats when compared to control rats. NG-Nitro-l-arginine (L-NO Arg), an inhibitor of NO synthase, was used as a tool to study the role of NO in food deprivation. Twenty-four hr food deprived male Sprague-Dawley rats were intraperitoneally (i.p.) administered L-NO Arg (12.5, 25 and 50 mg/kg) before food presentation. Control rats received a NaCl (0.9%) solution. Food consumption was monitored 1 and 2 hr after food presentation. L-NO Arg administration produced a dose-dependent reduction in food intake. Pretreatment with metergoline (2 mg/kg) but not with ritanserin (1 mg/kg) antagonized the anorectic effect of L-NO Arg. Moreover, in the diencephalon L-NO Arg significantly reduced NO synthase activity whereas it increased serotonin levels. Our data indicate that NO might have a physiological role in the regulation of food intake and suggest that brain NO may modulate the central serotoninergic system.
DOI：
10.1073/pnas.87.2.682
发表时间：
1990-01-01
影响因子：
11.1
作者：
BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH
DOI：
10.1073/pnas.84.24.9265
发表时间：
1987-12-01
影响因子：
11.1
作者：
IGNARRO, LJ;BUGA, GM;CHAUDHURI, G
通讯作者：
CHAUDHURI, G
DOI：
10.1016/0006-291x(91)90403-t
发表时间：
1991-05-15
影响因子：
3.1
作者：
DWYER, MA;BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH